{"id":"W2283133204","doi":"10.1038/nchem.2451","title":"Reprogramming the assembly of unmodified DNA with a small molecule","year":2016,"lang":"en","type":"article","venue":"Nature Chemistry","topic":"Advanced biosensing and bioanalysis techniques","field":"Biochemistry, Genetics and Molecular Biology","cited_by":146,"is_retracted":false,"has_abstract":false,"ca_institutions":"Institut National de la Recherche Scientifique; Queen's University; McGill University","funders":"","keywords":"Nucleic acid; Chemistry; Nucleobase; DNA; Peptide nucleic acid; Base pair; Thymine; Nucleic acid structure; RNA; Molecule; Combinatorial chemistry; Small molecule; Nucleic acid analogue; Nucleic acid thermodynamics; Biochemistry; Organic chemistry; Base sequence","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001363015,0.0001493818,0.0001352772,0.00001052724,0.00004891038,0.000009878071,0.0002337798,0.0003395507,0.000001645291],"category_scores_gemma":[0.0001355352,0.00007090724,0.00009985902,0.0001206937,0.0001727191,0.000001744509,0.00007093305,0.0001643879,3.573383e-7],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00001102475,"about_ca_system_score_gemma":0.00004357307,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000002184522,"about_ca_topic_score_gemma":0.000006254448,"domain_scores_codex":[0.9991773,0.00001789494,0.0001469516,0.0003422396,0.000132531,0.0001830432],"domain_scores_gemma":[0.9990562,0.00001951224,0.0001390335,0.0005881146,0.0001552432,0.00004191569],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00008165697,0.00002887676,0.000191766,0.00001694434,0.0000618293,0.000003563949,0.00000373279,3.163198e-7,0.9943448,0.00001133611,0.0002582784,0.00499687],"study_design_scores_gemma":[0.0002341213,0.00005896934,0.00006340101,0.00005172339,0.00003373186,0.00002853916,0.00002793172,0.000001560736,0.9914054,0.00002372094,0.007935795,0.0001351268],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9943191,0.000430982,0.002778045,0.0005195975,0.00001355425,0.00008482581,0.00001093343,0.00003849934,0.001804427],"genre_scores_gemma":[0.9953482,0.00005942554,0.00332203,0.0001290838,0.0001151375,0.00000844095,0.00002445553,0.00001749171,0.0009756943],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.007677516,"threshold_uncertainty_score":0.2891513,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.006597466141064583,"score_gpt":0.2446271687661432,"score_spread":0.2380297026250786,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}