{"id":"W2283150954","doi":"10.1021/acs.nanolett.5b04877","title":"Potentiating Cancer Immunotherapy Using Papaya Mosaic Virus-Derived Nanoparticles","year":2016,"lang":"en","type":"article","venue":"Nano Letters","topic":"Immunotherapy and Immune Responses","field":"Immunology and Microbiology","cited_by":137,"is_retracted":false,"has_abstract":true,"ca_institutions":"Université Laval; Institut National de la Recherche Scientifique","funders":"Canadian Institutes of Health Research; Fonds de Recherche du Québec - Santé; Fondation Jean-Louis Lévesque; Canadian Institute for Advanced Research","keywords":"Immune system; Immunotherapy; Adjuvant; Cancer immunotherapy; Chemokine; Oncolytic virus; Cancer vaccine; Cancer research; Immunology; Immune checkpoint; CD8; Medicine; Cancer; Dendritic cell; T cell; Vaccination; Melanoma; Internal medicine","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["insufficient_payload"],"consensus_categories":[],"category_scores_codex":[0.0002469654,0.0002870281,0.0003273649,0.0001304318,0.0003787608,0.0000341333,0.000319012,0.0001817109,0.001176092],"category_scores_gemma":[0.000042193,0.0001988757,0.000180122,0.0001724181,0.0003310117,0.000278354,0.00005744605,0.0001281898,0.0002475313],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000132645,"about_ca_system_score_gemma":0.00007294798,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0006309056,"about_ca_topic_score_gemma":0.00001519365,"domain_scores_codex":[0.9981222,0.0003770571,0.0004108286,0.0003590126,0.00006382728,0.0006670827],"domain_scores_gemma":[0.9991235,0.0001904196,0.0002063445,0.0004122059,0.00004844703,0.00001907818],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0006058852,0.00005601254,0.001198445,0.000005420953,0.0003302877,0.000004984398,0.0004540136,0.000009042092,0.961131,0.00002106969,0.001453465,0.03473032],"study_design_scores_gemma":[0.002387948,0.00006638745,0.002317873,0.0001274973,0.00002947705,0.00003651419,0.00006368896,0.000001223609,0.9369424,0.0000145727,0.05769099,0.0003214268],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9831232,0.01163576,0.0007643402,0.002809248,0.001162074,0.0002106428,0.00004720921,0.0002348056,0.00001271322],"genre_scores_gemma":[0.9944411,0.000970421,0.0002277111,0.00341502,0.00006100928,0.00004414946,0.00001014497,0.00008473782,0.0007457145],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.05623753,"threshold_uncertainty_score":0.999737,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01655214074274477,"score_gpt":0.2517663593912247,"score_spread":0.2352142186484799,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}