{"id":"W2283432493","doi":"10.1038/srep18198","title":"Structural and functional interactions between six-transmembrane μ-opioid receptors and β2-adrenoreceptors modulate opioid signaling","year":2015,"lang":"en","type":"article","venue":"Scientific Reports","topic":"Receptor Mechanisms and Signaling","field":"Biochemistry, Genetics and Molecular Biology","cited_by":39,"is_retracted":false,"has_abstract":true,"ca_institutions":"McGill University","funders":"National Institute on Drug Abuse; National Institute of Neurological Disorders and Stroke; Pfizer Canada; Canada Excellence Research Chairs, Government of Canada; National Institute of Dental and Craniofacial Research; Louise and Alan Edwards Foundation; Pfizer","keywords":"Receptor; Opioid; Pharmacology; Signal transduction; Chemistry; Opioid receptor; Transmembrane protein; Hyperalgesia; Cell biology; Transmembrane domain; Neuroscience; Biology; Nociception; Biochemistry","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0007705136,0.0002264508,0.0002196934,0.0001237277,0.0003753095,0.0002645311,0.00007597163,0.000133568,0.0001980252],"category_scores_gemma":[0.00009394051,0.0002060511,0.00008160425,0.0001674531,0.0002297512,0.00003516962,0.0001070423,0.0001496022,0.000004225907],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00002674553,"about_ca_system_score_gemma":0.000125241,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00003863769,"about_ca_topic_score_gemma":0.00002235723,"domain_scores_codex":[0.9979964,0.00005947817,0.0004385502,0.0008524894,0.0003408326,0.0003121985],"domain_scores_gemma":[0.9989171,0.000017385,0.0001940516,0.0003378493,0.0002043501,0.0003292727],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0000336025,0.00001313303,0.01454488,0.00002548101,0.00006769373,0.00001083526,0.0004245375,0.000467697,0.9772804,0.00003064754,0.002488887,0.004612167],"study_design_scores_gemma":[0.0005165589,0.0001901532,0.001998238,0.00005624653,0.00007440105,0.0003541107,0.0005493711,0.00044911,0.9255237,0.005079153,0.06462818,0.0005807913],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9907764,0.0006129949,0.00173858,0.00005118057,0.006445667,0.0001997103,0.000009011624,0.0000304894,0.000135979],"genre_scores_gemma":[0.9960015,0.00001850207,0.001418891,0.0000233766,0.0004940735,0.00001158222,0.0004534808,0.00002685482,0.001551702],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0621393,"threshold_uncertainty_score":0.8402518,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0218277880672717,"score_gpt":0.2465528647792194,"score_spread":0.2247250767119477,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}