{"id":"W2283437114","doi":"10.1093/neuonc/nov165","title":"Neddylation in glioblastomas","year":2015,"lang":"en","type":"letter","venue":"Neuro-Oncology","topic":"Ubiquitin and proteasome pathways","field":"Biochemistry, Genetics and Molecular Biology","cited_by":7,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Toronto","funders":"","keywords":"Neddylation; NEDD8; Cullin; Ubiquitin ligase; Ubiquitin; Cell biology; Cell cycle; Biology; Cancer cell; Protein degradation; Chemistry; Biochemistry; Cancer; Cell; Genetics","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow","research_integrity"],"consensus_categories":[],"category_scores_codex":[0.0003159309,0.0003271223,0.0004109972,0.000178154,0.00003657907,0.00002016745,0.0003641242,0.002049494,0.0000813531],"category_scores_gemma":[0.0002820823,0.0003430991,0.0001185813,0.0001371764,0.0001045061,0.000003442193,0.0002145314,0.001314792,0.0001844551],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001261335,"about_ca_system_score_gemma":0.0006344132,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0000310874,"about_ca_topic_score_gemma":0.0001419546,"domain_scores_codex":[0.9977486,0.0004873457,0.0003761809,0.0006752605,0.0002203429,0.0004922385],"domain_scores_gemma":[0.9989961,0.00006986338,0.0002222572,0.0005072577,0.0001183669,0.00008619801],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"not_applicable","study_design_gemma":"not_applicable","study_design_scores_codex":[0.00008696506,0.00003208913,0.0001030731,0.00002877601,0.0000128733,0.0004342653,0.00004550144,0.00001113099,0.2252876,0.000005882944,0.7693085,0.004643389],"study_design_scores_gemma":[0.0007475378,0.001356532,0.00002303972,0.00001226755,0.00001605591,0.0001632761,0.000008715599,0.00002028843,0.04571493,0.0001845178,0.9514534,0.0002994104],"study_design_candidate":"not_applicable","study_design_consensus":"not_applicable","genre_codex":"commentary","genre_gemma":"commentary","genre_scores_codex":[0.1075828,0.002588021,0.0002288916,0.7502056,0.006043205,0.002499093,0.0002934464,0.0001762602,0.1303827],"genre_scores_gemma":[0.02981482,0.0002529506,0.0005159437,0.9528929,0.01212497,0.0002825384,0.002119156,0.0001841988,0.001812496],"genre_candidate":"commentary","genre_consensus":"commentary","teacher_disagreement_score":0.2026873,"threshold_uncertainty_score":0.9999021,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02547768577843626,"score_gpt":0.2814523645490649,"score_spread":0.2559746787706287,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}