{"id":"W2283563018","doi":"10.3390/cells5010003","title":"The Role of G-Protein-Coupled Receptor Proteolysis Site Cleavage of Polycystin-1 in Renal Physiology and Polycystic Kidney Disease","year":2016,"lang":"en","type":"review","venue":"Cells","topic":"Genetic and Kidney Cyst Diseases","field":"Biochemistry, Genetics and Molecular Biology","cited_by":62,"is_retracted":false,"has_abstract":true,"ca_institutions":"Université de Montréal; Montreal Clinical Research Institute","funders":"National Institute of Diabetes and Digestive and Kidney Diseases; National Institutes of Health; PKD Australia; PKD Foundation","keywords":"Polycystic kidney disease; PKD1; Biogenesis; Autosomal dominant polycystic kidney disease; Cleavage (geology); Biology; Cell biology; Intracellular; Proteolysis; Kidney; Endocrinology; Chemistry; Genetics; Biochemistry","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001794079,0.0003626737,0.0008674553,0.00008447171,0.00005386286,0.000009925271,0.0003588099,0.0002633271,0.00003333312],"category_scores_gemma":[0.0003065669,0.0002262601,0.0003562121,0.0001305457,0.0003786554,0.000002196441,0.0002427267,0.0001124053,0.00001857349],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0000134077,"about_ca_system_score_gemma":0.0006083066,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00002230677,"about_ca_topic_score_gemma":0.000001956571,"domain_scores_codex":[0.9980883,0.0002627586,0.0006458027,0.0005194754,0.0001463616,0.000337314],"domain_scores_gemma":[0.9983437,0.00006336468,0.0005220158,0.0006869149,0.00005591322,0.0003280778],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"not_applicable","study_design_scores_codex":[0.0004433985,0.00009880943,0.00001749522,0.003969636,0.0001696811,0.000002515658,0.00001137952,2.548435e-7,0.9131046,0.000009155376,0.0005390328,0.08163404],"study_design_scores_gemma":[0.0005913152,0.0002256531,0.00007871439,0.004392264,0.0004090056,0.00000270832,0.00001424562,0.000005109978,0.1741353,0.0001352797,0.8195864,0.0004240217],"study_design_candidate":"bench_or_experimental","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.009167871,0.9887974,0.00001411377,0.00001841239,0.00008383409,0.001047461,0.0007442708,0.000004741948,0.0001218464],"genre_scores_gemma":[0.0209796,0.9773186,0.0001002396,0.00002351076,0.0001725801,0.0002021202,0.0002716267,0.00005140369,0.0008803337],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.8190473,"threshold_uncertainty_score":0.922662,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.005565094378760015,"score_gpt":0.2327035579416059,"score_spread":0.2271384635628459,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}