{"id":"W2283563018","doi":"10.3390/cells5010003","title":"The Role of G-Protein-Coupled Receptor Proteolysis Site Cleavage of Polycystin-1 in Renal Physiology and Polycystic Kidney Disease","year":2016,"lang":"en","type":"review","venue":"Cells","topic":"Genetic and Kidney Cyst Diseases","field":"Biochemistry, Genetics and Molecular Biology","cited_by":62,"is_retracted":false,"has_abstract":true,"ca_institutions":"Université de Montréal; Montreal Clinical Research Institute","funders":"National Institute of Diabetes and Digestive and Kidney Diseases; National Institutes of Health; PKD Australia; PKD Foundation","keywords":"Polycystic kidney disease; PKD1; Biogenesis; Autosomal dominant polycystic kidney disease; Cleavage (geology); Biology; Cell biology; Intracellular; Proteolysis; Kidney; Endocrinology; Chemistry; Genetics; Biochemistry","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0004339253,0.0005822367,0.0009444759,0.001816615,0.0002414201,0.0007465378,0.0005853084,0.0008302119,0.001704092],"category_scores_gemma":[0.0005123155,0.0001776733,0.0003695764,0.001781987,0.0004793169,0.0009822325,0.0006847623,0.001371233,0.001257762],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000540976,"about_ca_system_score_gemma":0.0009694051,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0007112887,"about_ca_topic_score_gemma":0.001135454,"domain_scores_codex":[0.9998531,0.00002077835,0.00002971171,0.00002409296,0.00005686368,0.00001545141],"domain_scores_gemma":[0.9997898,0.00007997912,0.00003593751,0.000007405962,0.00005878726,0.0000280767],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.00009070043,0.00005020191,0.0003123355,0.01332824,0.00009292379,0.0004026431,0.00006623223,0.0002903446,0.003135043,0.003861662,0.02315077,0.9552189],"study_design_scores_gemma":[0.00001713106,0.00008099203,0.001283167,0.00207687,0.0001135594,0.003237485,0.00005911342,0.00007402057,0.001049057,0.002317977,0.9896721,0.00001852448],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.0001146278,0.998978,0.00008109055,0.0002076011,0.0001203113,0.000001713354,0.00000983379,0.000004561324,0.0004823176],"genre_scores_gemma":[0.0006683748,0.9986662,0.0001026645,0.0001026541,0.00009076521,0.000002396358,0.00001848756,9.152822e-7,0.0003476194],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.001816615,"threshold_uncertainty_score":0.005700767,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.005565094378760015,"score_gpt":0.2327035579416059,"score_spread":0.2271384635628459,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}