{"id":"W2283571135","doi":"10.1161/atvb.35.suppl_1.689","title":"Abstract 689: Cystathionine-Beta-Synthase Deficiency Induces Cardiac Hypertrophy and Contributes to Diminished Fatty Acid Oxidation in Mice with Diet-Induced Obesity","year":2015,"lang":"en","type":"article","venue":"Arteriosclerosis Thrombosis and Vascular Biology","topic":"Folate and B Vitamins Research","field":"Medicine","cited_by":1,"is_retracted":false,"has_abstract":true,"ca_institutions":"Allard Foundation; University of Alberta; Okanagan University College; University of British Columbia","funders":"","keywords":"Internal medicine; Endocrinology; Cystathionine beta synthase; Lipotoxicity; Docosahexaenoic acid; Beta oxidation; Chemistry; Fatty acid; Biology; Polyunsaturated fatty acid; Medicine; Obesity; Metabolism; Cysteine; Biochemistry; Insulin resistance","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002542938,0.001103647,0.0006424222,0.0008875445,0.0003624021,0.0003877542,0.0005138997,0.0007559755,0.004561915],"category_scores_gemma":[0.0001460033,0.0005104941,0.0004939756,0.0003687983,0.0005565112,0.0003568177,0.0003844412,0.001331725,0.001641103],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003341419,"about_ca_system_score_gemma":0.0002843119,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0004787938,"about_ca_topic_score_gemma":0.0006836568,"domain_scores_codex":[0.9997107,0.00004309073,0.00005066837,0.00006525217,0.00007509469,0.00005518778],"domain_scores_gemma":[0.999617,0.000028254,0.0001221623,0.00003749264,0.00003026876,0.0001648275],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.001486053,0.0001911042,0.0004213515,0.00006892373,0.00001625863,0.0002018388,0.00002401041,0.00002756354,0.9958983,0.00007108707,0.0001288256,0.00146475],"study_design_scores_gemma":[0.0009801824,0.003974715,0.03948123,0.00009397962,0.0002296879,0.003386429,0.0001986682,0.001224238,0.9439283,0.0003452538,0.006121895,0.00003544119],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9921228,0.001486877,0.001896591,0.0004907807,0.0001080879,0.00006570313,0.001708103,0.0002825564,0.001838534],"genre_scores_gemma":[0.9772518,0.002163834,0.003664744,0.0004670615,0.0001071361,0.0002837061,0.003299945,0.0002464977,0.01251536],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.004561915,"threshold_uncertainty_score":0.01526105,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.05913387273006349,"score_gpt":0.3041059029481045,"score_spread":0.244972030218041,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}