{"id":"W2283761750","doi":"10.3747/co.23.2806","title":"Targeting Leukemia Stem Cells: Which Pathways Drive Self-Renewal Activity in T-Cell Acute Lymphoblastic Leukemia?","year":2016,"lang":"en","type":"review","venue":"Current Oncology","topic":"Epigenetics and DNA Methylation","field":"Biochemistry, Genetics and Molecular Biology","cited_by":24,"is_retracted":false,"has_abstract":true,"ca_institutions":"BC Cancer Agency","funders":"Medical Research Council; Canadian Institutes of Health Research; Terry Fox Foundation","keywords":"Stem cell; Haematopoiesis; Leukemia; Progenitor cell; Cancer research; Bone marrow; Medicine; Cancer stem cell; Immunology; Cell division; Biology; Lymphoblastic Leukemia; Stem cell theory of aging; Cell; Cell biology; Stem cell factor; Genetics","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":true,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003793663,0.0005310448,0.0009543397,0.001129711,0.0001964449,0.0006309562,0.0007069141,0.0008869049,0.002255448],"category_scores_gemma":[0.0004753536,0.0002114936,0.0003808736,0.0009620709,0.0003316035,0.001125137,0.0004731419,0.001355803,0.001409596],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004832284,"about_ca_system_score_gemma":0.0005701839,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0006113368,"about_ca_topic_score_gemma":0.001173981,"domain_scores_codex":[0.9998913,0.00001768829,0.00001716184,0.00002008835,0.00004070263,0.00001314547],"domain_scores_gemma":[0.9998841,0.00004876597,0.00001918161,0.00000401912,0.0000312908,0.00001250607],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.00009382594,0.00005490536,0.0001818714,0.0142901,0.00007843362,0.0002212988,0.00006771713,0.0003762567,0.005190359,0.004407988,0.02016547,0.9548719],"study_design_scores_gemma":[0.00002105113,0.0001083408,0.0005566804,0.001935104,0.0001179526,0.001430372,0.00004289012,0.0000990541,0.001876231,0.001817141,0.9919782,0.00001688426],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.0002055603,0.9983667,0.0001682745,0.0002833096,0.0001471573,0.000004280193,0.00001950821,0.000008664041,0.0007966689],"genre_scores_gemma":[0.001012381,0.9979671,0.000171114,0.0001868421,0.00008743149,0.000006407337,0.00003484683,0.000001943882,0.0005319303],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.002255448,"threshold_uncertainty_score":0.007545173,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.04846639510199854,"score_gpt":0.3389138072735257,"score_spread":0.2904474121715272,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}