{"id":"W2283830632","doi":"10.1007/s00401-016-1544-2","title":"Monomethylated and unmethylated FUS exhibit increased binding to Transportin and distinguish FTLD-FUS from ALS-FUS","year":2016,"lang":"en","type":"article","venue":"Acta Neuropathologica","topic":"Cancer-related gene regulation","field":"Biochemistry, Genetics and Molecular Biology","cited_by":93,"is_retracted":false,"has_abstract":false,"ca_institutions":"Vancouver General Hospital; University of British Columbia","funders":"Instituto de Salud Carlos III; European Research Council; School of Medicine, Vanderbilt University; NOMIS Stiftung; Deutsche Stiftung für Herzforschung; Holcim Stiftung zur Förderung der Wissenschaftlichen Fortbildung; Bayerisches Staatsministerium für Wissenschaft, Forschung und Kunst; National Natural Science Foundation of China; Deutsche Forschungsgemeinschaft; European Commission; Vanderbilt University","keywords":"Frontotemporal lobar degeneration; Molecular biology; Arginine; Biology; Chemistry; Biochemistry; Pathology; Medicine; Amino acid","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002644742,0.0002936412,0.0002906867,0.00009825541,0.000131887,0.00004278543,0.0001636275,0.0002786914,0.00005633539],"category_scores_gemma":[0.0006077008,0.0002285398,0.0000634341,0.0002100593,0.0001340443,0.0000106197,0.0001480942,0.0001233722,0.00001158067],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00002215624,"about_ca_system_score_gemma":0.00002824741,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00008108898,"about_ca_topic_score_gemma":0.00003106681,"domain_scores_codex":[0.9980463,0.0002077977,0.0003773593,0.0008734808,0.0001318378,0.0003632284],"domain_scores_gemma":[0.9990109,0.00009700975,0.0001827484,0.000409403,0.00006965282,0.0002303522],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0002452458,0.00003117937,0.01199281,0.00000543851,0.00002281969,0.00005564432,0.00006286335,0.000004841199,0.9646606,0.000002797155,0.0001376079,0.02277813],"study_design_scores_gemma":[0.001682976,0.0007746679,0.4324562,0.00006458723,0.0000918506,0.00007150926,0.00002422162,0.00004417438,0.5546864,0.0001213931,0.009404594,0.0005774344],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9973051,0.0007730341,0.0003561268,0.0006185315,0.0001566696,0.0003264153,0.0001761148,0.00007715603,0.0002108724],"genre_scores_gemma":[0.9981957,0.0005092827,0.0004926144,0.000216475,0.0001607412,0.00002312082,0.0001544461,0.00004578068,0.0002018099],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.4204634,"threshold_uncertainty_score":0.9319584,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.00913358895495722,"score_gpt":0.2230770548438092,"score_spread":0.213943465888852,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}