{"id":"W2284198291","doi":"10.1371/journal.pone.0148753","title":"Degradation, Promoter Recruitment and Transactivation Mediated by the Extreme N-Terminus of MHC Class II Transactivator CIITA Isoform III","year":2016,"lang":"en","type":"article","venue":"PLoS ONE","topic":"Ubiquitin and proteasome pathways","field":"Biochemistry, Genetics and Molecular Biology","cited_by":9,"is_retracted":false,"has_abstract":true,"ca_institutions":"Université de Sherbrooke","funders":"Natural Sciences and Engineering Research Council of Canada; Canadian Institutes of Health Research","keywords":"CIITA; Transactivation; Biology; Gene isoform; Molecular biology; Cell biology; Proteasome; Degron; Ubiquitin; Protein degradation; Transcription factor; Ubiquitin ligase; Major histocompatibility complex; MHC class II; Biochemistry; Gene","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001554613,0.000210401,0.000159455,0.000118012,0.0001581921,0.0003340148,0.0001600448,0.0001359553,0.0008098145],"category_scores_gemma":[0.0001586751,0.0001071831,0.0002812559,0.0001151027,0.0001782931,0.0001351986,0.0002013444,0.0004827259,0.0005779576],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000389199,"about_ca_system_score_gemma":0.0002356093,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0005432359,"about_ca_topic_score_gemma":0.000614522,"domain_scores_codex":[0.999866,0.00001354294,0.00001443656,0.00003575352,0.00003310968,0.0000371096],"domain_scores_gemma":[0.9998099,0.00002300687,0.00005969135,0.00003218169,0.0000310349,0.00004425152],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00004259342,0.000004031205,0.000182079,0.000008740965,0.000001465169,0.00002067439,0.000006404322,0.00001750708,0.9993981,0.00002750665,0.000007991017,0.0002829024],"study_design_scores_gemma":[0.000007588156,0.00006388445,0.01009006,0.000006477366,0.000007076008,0.0003850297,0.0000417158,0.0007475662,0.9865853,0.00004008209,0.002020908,0.000004330988],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.993606,0.001290794,0.003663382,0.00004142917,0.00002011733,0.00001106781,0.0002120669,0.00003481447,0.001120277],"genre_scores_gemma":[0.9933848,0.0006019683,0.002394944,0.00004095602,0.00001067707,0.00002400351,0.001028955,0.0000297026,0.002483986],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0008098145,"threshold_uncertainty_score":0.002823889,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.06476589454220621,"score_gpt":0.2314654685094456,"score_spread":0.1666995739672394,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}