{"id":"W2284494162","doi":"10.1111/hae.12890","title":"Reduced immunogenic response to residual <scp>CHO</scp> cell protein in recombinant factor <scp>IX</scp> (<scp>IB</scp>1001) drug product in normal healthy rabbits","year":2016,"lang":"en","type":"letter","venue":"Haemophilia","topic":"Protein purification and stability","field":"Biochemistry, Genetics and Molecular Biology","cited_by":9,"is_retracted":false,"has_abstract":true,"ca_institutions":"Emergent BioSolutions (Canada)","funders":"","keywords":"Chinese hamster ovary cell; Recombinant DNA; Immunogenicity; Factor IX; CHOP; Medicine; Antibody; Haemophilia; Adjuvant; Haemophilia B; Polyclonal antibodies; Immunology; Haemophilia A; Pharmacology; Virology; Molecular biology; Chemistry; Biology; Internal medicine; Biochemistry; Receptor; Surgery","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaresearch","metaepi_narrow","research_integrity"],"consensus_categories":["metaepi_narrow","research_integrity"],"category_scores_codex":[0.00370094,0.001500892,0.001497154,0.0009110323,0.0002978831,0.0001771778,0.002081879,0.002144063,0.00002645914],"category_scores_gemma":[0.008599432,0.001423981,0.0005075642,0.0009685352,0.0003547413,0.00005433854,0.0008058731,0.002857966,0.0004460937],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0006696195,"about_ca_system_score_gemma":0.002094055,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002428246,"about_ca_topic_score_gemma":0.000223113,"domain_scores_codex":[0.9874718,0.00305396,0.002246517,0.003457755,0.001073936,0.002696088],"domain_scores_gemma":[0.9934394,0.0007526074,0.0009959711,0.003714454,0.0005268343,0.0005706892],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"not_applicable","study_design_scores_codex":[0.0003851707,0.0004379347,0.0006021583,0.0005589321,0.00007546663,0.0002184306,0.001311669,0.000005061098,0.5954064,0.000005456748,0.3991249,0.001868462],"study_design_scores_gemma":[0.001851776,0.0005364201,0.006712748,0.000237289,0.00001934184,0.00003431315,0.0001460097,0.000001812983,0.3954347,0.0001384162,0.5946718,0.0002152658],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9209825,0.004520132,0.00002337573,0.06376993,0.001275091,0.007590886,0.0007823314,0.0001218894,0.0009338442],"genre_scores_gemma":[0.7316456,0.001259852,0.001394397,0.06316528,0.006123766,0.006776433,0.00330062,0.0008535529,0.1854805],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.1999716,"threshold_uncertainty_score":0.999774,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01428784131868048,"score_gpt":0.2492027332125639,"score_spread":0.2349148918938835,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}