{"id":"W2284494162","doi":"10.1111/hae.12890","title":"Reduced immunogenic response to residual <scp>CHO</scp> cell protein in recombinant factor <scp>IX</scp> (<scp>IB</scp>1001) drug product in normal healthy rabbits","year":2016,"lang":"en","type":"letter","venue":"Haemophilia","topic":"Protein purification and stability","field":"Biochemistry, Genetics and Molecular Biology","cited_by":9,"is_retracted":false,"has_abstract":true,"ca_institutions":"Emergent BioSolutions (Canada)","funders":"","keywords":"Chinese hamster ovary cell; Recombinant DNA; Immunogenicity; Factor IX; CHOP; Medicine; Antibody; Haemophilia; Adjuvant; Haemophilia B; Polyclonal antibodies; Immunology; Haemophilia A; Pharmacology; Virology; Molecular biology; Chemistry; Biology; Internal medicine; Biochemistry; Receptor; Surgery","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0004021855,0.0005088125,0.0004047104,0.0005340384,0.0001765075,0.0004253831,0.0002031924,0.0007957473,0.001715146],"category_scores_gemma":[0.0007200505,0.0002560802,0.0004908033,0.0001728899,0.0003518622,0.0002984324,0.0002289346,0.001419846,0.0008957403],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003926904,"about_ca_system_score_gemma":0.0001316653,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0005612235,"about_ca_topic_score_gemma":0.0003320011,"domain_scores_codex":[0.9994975,0.0001028148,0.00004283267,0.0001262144,0.0001180069,0.0001127391],"domain_scores_gemma":[0.99944,0.0001523101,0.0001279324,0.00008665944,0.000068727,0.0001243024],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0008628238,0.0002603837,0.0002576128,0.00005174085,0.00001029565,0.0001461971,0.00006479812,0.00004412986,0.9973093,0.0000420363,0.00005655043,0.0008940904],"study_design_scores_gemma":[0.0001457599,0.01948129,0.01574422,0.00002340641,0.0000904445,0.001499058,0.0001184091,0.001004802,0.959188,0.00009967775,0.002586448,0.00001853854],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9971157,0.0009418913,0.0005740981,0.00005604032,0.00004801751,0.00003556451,0.0001571472,0.00004072016,0.001030846],"genre_scores_gemma":[0.9956898,0.0005792133,0.0003832556,0.00008878425,0.00003094857,0.00004902945,0.0004830314,0.00002503355,0.002670866],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001715146,"threshold_uncertainty_score":0.005737782,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01428784131868048,"score_gpt":0.2492027332125639,"score_spread":0.2349148918938835,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}