{"id":"W2284549295","doi":"10.1038/nature16963","title":"Inhibiting fungal multidrug resistance by disrupting an activator–Mediator interaction","year":2016,"lang":"en","type":"article","venue":"Nature","topic":"Antifungal resistance and susceptibility","field":"Medicine","cited_by":143,"is_retracted":false,"has_abstract":false,"ca_institutions":"","funders":"National Institute of Biomedical Imaging and Bioengineering; National Institute of Diabetes and Digestive and Kidney Diseases; National Institute of General Medical Sciences; Natural Sciences and Engineering Research Council of Canada","keywords":"Mediator; Activator (genetics); Candida glabrata; Transcription factor; Biology; Gene; Protein subunit; RNA polymerase II; Transcription (linguistics); Gene expression; Cell biology; Genetics; Promoter; Candida albicans","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003082911,0.0001792542,0.0002417495,0.00004980634,0.0001353461,0.00002540878,0.00009287323,0.0007098516,0.0001441609],"category_scores_gemma":[0.001419248,0.0001166771,0.00009361006,0.0001483394,0.00007062277,0.0005301167,0.00003118205,0.001466171,0.00003539717],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002254516,"about_ca_system_score_gemma":0.0000670423,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000006699968,"about_ca_topic_score_gemma":0.0001048307,"domain_scores_codex":[0.9985082,0.00006832668,0.0002560788,0.0004604142,0.0003874114,0.0003196407],"domain_scores_gemma":[0.9989008,0.0002722549,0.0001320332,0.0003396911,0.0001516034,0.0002035839],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.001062668,0.0001712193,0.1347156,0.0001124577,0.00002851805,0.00004437656,0.0002991725,5.881683e-8,0.8310563,0.0001463105,0.01596825,0.01639507],"study_design_scores_gemma":[0.004657701,0.0003076622,0.1944623,0.002059992,0.0001096237,0.0000429049,0.002951427,0.00008178302,0.6818525,0.0001977931,0.1124605,0.0008158979],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9943854,0.0005572663,0.0001727227,0.002121558,0.0003881012,0.0001885999,0.00005178774,0.0001361079,0.001998445],"genre_scores_gemma":[0.9946399,0.00003880171,0.000559781,0.0005378489,0.0005578685,0.000009009747,0.00003163777,0.00003077483,0.003594332],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.1492038,"threshold_uncertainty_score":0.6369864,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01027982718410084,"score_gpt":0.3099360025075382,"score_spread":0.2996561753234374,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}