{"id":"W2284549295","doi":"10.1038/nature16963","title":"Inhibiting fungal multidrug resistance by disrupting an activator–Mediator interaction","year":2016,"lang":"en","type":"article","venue":"Nature","topic":"Antifungal resistance and susceptibility","field":"Medicine","cited_by":143,"is_retracted":false,"has_abstract":false,"ca_institutions":"","funders":"National Institute of Biomedical Imaging and Bioengineering; National Institute of Diabetes and Digestive and Kidney Diseases; National Institute of General Medical Sciences; Natural Sciences and Engineering Research Council of Canada","keywords":"Mediator; Activator (genetics); Candida glabrata; Transcription factor; Biology; Gene; Protein subunit; RNA polymerase II; Transcription (linguistics); Gene expression; Cell biology; Genetics; Promoter; Candida albicans","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0004062192,0.0003977677,0.0003003794,0.0003529495,0.0003995657,0.0007694015,0.0006518196,0.0005128972,0.005283584],"category_scores_gemma":[0.0003558241,0.0002114371,0.0003439841,0.0002113982,0.0004200541,0.0004298896,0.0005640239,0.001381709,0.0010369],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004216597,"about_ca_system_score_gemma":0.0004246024,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001948523,"about_ca_topic_score_gemma":0.0003497362,"domain_scores_codex":[0.9997208,0.0000418288,0.00002534545,0.00005155409,0.00007730061,0.0000831119],"domain_scores_gemma":[0.9997552,0.00007324136,0.00006578725,0.00002901905,0.0000158178,0.00006089481],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0005243879,0.0000828735,0.0002916009,0.0000385535,0.00001663795,0.0001162594,0.00002041007,0.0001782169,0.9937256,0.001762994,0.0001903,0.003052251],"study_design_scores_gemma":[0.0001452525,0.0002483969,0.001316904,0.000009244472,0.00003623021,0.0003657697,0.00003458681,0.001356888,0.9852744,0.0005147633,0.01068621,0.00001126098],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9589514,0.006140145,0.02171664,0.001781098,0.000623352,0.0001163709,0.0006461493,0.0005284589,0.009496401],"genre_scores_gemma":[0.9897628,0.001236677,0.004888241,0.0001481015,0.00004875517,0.00005183026,0.000276405,0.00003824793,0.003548975],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.005283584,"threshold_uncertainty_score":0.0176754,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01027982718410084,"score_gpt":0.3099360025075382,"score_spread":0.2996561753234374,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}