{"id":"W2284555999","doi":"10.1182/blood.v122.21.1548.1548","title":"DNA Demethylation Activity Over Time and Safety Of 3 Different Dose-Escalation Regimens Of SGI-110, a Novel Subcutaneous (SQ) Hypomethylating Agent (HMA), In The Treatment Of Relapsed/Refractory Patients With MDS and AML","year":2013,"lang":"en","type":"article","venue":"Blood","topic":"Epigenetics and DNA Methylation","field":"Biochemistry, Genetics and Molecular Biology","cited_by":1,"is_retracted":false,"has_abstract":true,"ca_institutions":"Princess Margaret Cancer Centre","funders":"","keywords":"Medicine; Regimen; Decitabine; Refractory (planetary science); Hypomethylating agent; Internal medicine; Neutropenia; Phases of clinical research; Surgery; Pharmacology; Clinical trial; Oncology; Gastroenterology; Toxicity; Chemistry","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0008242559,0.0004744459,0.0009304428,0.0003382634,0.0001790689,0.0003891891,0.0003533687,0.0003805459,0.001455936],"category_scores_gemma":[0.0006006778,0.0002864267,0.0005717577,0.0002668972,0.0004725789,0.0004154765,0.0002086048,0.001524566,0.0002045523],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0005110009,"about_ca_system_score_gemma":0.0003844119,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0004154569,"about_ca_topic_score_gemma":0.00107378,"domain_scores_codex":[0.99962,0.0001695695,0.00003127263,0.00007114202,0.00004525146,0.00006284629],"domain_scores_gemma":[0.9996631,0.00006886176,0.00009329264,0.0000427565,0.00001529954,0.0001166945],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"nonrandomized_trial","study_design_scores_codex":[0.5032286,0.05658842,0.02023724,0.0004279303,0.0009436854,0.0001703623,0.0005868054,0.007138588,0.2017735,0.0003732143,0.001291638,0.2072399],"study_design_scores_gemma":[0.09655832,0.8082556,0.04512001,0.00002481352,0.000629767,0.0003091253,0.0001107138,0.00532695,0.04157513,0.0002723041,0.00177074,0.00004655904],"study_design_candidate":"nonrandomized_trial","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9991277,0.0003765667,0.0001086169,0.00002776245,0.000009437395,0.00008838299,0.00006013285,0.00001314177,0.0001883327],"genre_scores_gemma":[0.9990785,0.0001603199,0.0002711731,0.00004167639,0.00001732474,0.00008317638,0.0001097402,0.00000363445,0.0002345282],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001455936,"threshold_uncertainty_score":0.004870594,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.007305438960826543,"score_gpt":0.2116185595971389,"score_spread":0.2043131206363123,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}