{"id":"W2284626840","doi":"10.1093/toxsci/kfv245","title":"Pyruvate Kinase Isoform Switching and Hepatic Metabolic Reprogramming by the Environmental Contaminant 2,3,7,8-Tetrachlorodibenzo-<i>p</i>-Dioxin","year":2015,"lang":"en","type":"article","venue":"Toxicological Sciences","topic":"Cancer, Hypoxia, and Metabolism","field":"Biochemistry, Genetics and Molecular Biology","cited_by":49,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Toronto","funders":"National Institute of General Medical Sciences; National Institute of Environmental Health Sciences; Canadian Institutes of Health Research","keywords":"PKM2; Glutaminolysis; Aryl hydrocarbon receptor; Glycolysis; Pyruvate kinase; Citric acid cycle; Biochemistry; Chemistry; Pentose phosphate pathway; Flux (metallurgy); Warburg effect; Biology; Metabolism; Transcription factor; Gene","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001113608,0.0001977416,0.0001467984,0.0002773696,0.000162234,0.0003301216,0.0001388641,0.0002227704,0.001628519],"category_scores_gemma":[0.0001221809,0.0001988592,0.0003331667,0.0003092725,0.0001708146,0.0001350547,0.000172089,0.0003586715,0.0004721943],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003851719,"about_ca_system_score_gemma":0.0002073126,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.002057714,"about_ca_topic_score_gemma":0.003151709,"domain_scores_codex":[0.9997823,0.0000184412,0.00001104268,0.00009163471,0.00004775763,0.00004878593],"domain_scores_gemma":[0.9999266,0.000007805394,0.00002585323,0.000009716897,0.00001441349,0.00001558143],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0002712567,0.00001337407,0.003428833,0.00002733684,0.00001081952,0.00003541555,0.00001818397,0.0001886044,0.9942624,0.0000800513,0.0001062898,0.001557485],"study_design_scores_gemma":[0.00002513163,0.0002940581,0.1868903,0.00001280151,0.00005258262,0.0002814364,0.0001529276,0.003031345,0.8030857,0.0002630285,0.005889272,0.00002137594],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9880252,0.0007464932,0.004063913,0.0001226347,0.00004495203,0.00002320283,0.004839551,0.0001309833,0.00200302],"genre_scores_gemma":[0.9870893,0.0006149961,0.002287832,0.0001741725,0.000009289391,0.00005104675,0.004910481,0.00004351702,0.004819285],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002057714,"threshold_uncertainty_score":0.005447924,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02341229036591993,"score_gpt":0.2616532081161917,"score_spread":0.2382409177502718,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}