{"id":"W2284684958","doi":"10.1016/j.brainres.2016.02.026","title":"Age-dependent increase of blood–brain barrier permeability and neuron-binding autoantibodies in S100B knockout mice","year":2016,"lang":"en","type":"article","venue":"Brain Research","topic":"S100 Proteins and Annexins","field":"Biochemistry, Genetics and Molecular Biology","cited_by":35,"is_retracted":false,"has_abstract":false,"ca_institutions":"University of Toronto","funders":"Rowan University; Osteopathic Heritage Foundation; New Jersey Health Foundation","keywords":"Glial fibrillary acidic protein; Blood–brain barrier; Autoantibody; Knockout mouse; Astrocyte; Microglia; Parenchyma; Immunology; Biology; Cell biology; Signal transduction; Receptor; Antibody; Neuroscience; Pathology; Immunohistochemistry; Central nervous system; Medicine; Inflammation; Biochemistry","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003700028,0.001441895,0.000884568,0.001888773,0.0003587038,0.0005947667,0.0006499122,0.001588414,0.004054426],"category_scores_gemma":[0.0004771868,0.0008466037,0.0007550368,0.000455394,0.0008578737,0.001257573,0.0005837287,0.00241767,0.0008854889],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0005976312,"about_ca_system_score_gemma":0.0003206686,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00103789,"about_ca_topic_score_gemma":0.001280325,"domain_scores_codex":[0.9994801,0.00004331214,0.00006458969,0.0001824396,0.0001210638,0.0001085839],"domain_scores_gemma":[0.9986513,0.000115225,0.0006053519,0.0001185829,0.0001084368,0.0004010529],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0004884294,0.00008453098,0.0003146256,0.00003189787,0.00001523668,0.0003167203,0.00004497313,0.00003806427,0.9977146,0.0001540015,0.00008836402,0.0007085625],"study_design_scores_gemma":[0.00009997626,0.0008190269,0.03299418,0.00002771558,0.0001389398,0.003063394,0.0001388421,0.001022264,0.9585639,0.0005327251,0.002560426,0.0000387195],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9885414,0.001910869,0.005203318,0.0004142335,0.0001553609,0.00003777318,0.001685468,0.0004794108,0.001572249],"genre_scores_gemma":[0.9787999,0.001843256,0.003875491,0.0002305271,0.00006647607,0.0001176764,0.00150375,0.0003584694,0.01320436],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.004054426,"threshold_uncertainty_score":0.01356339,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03178646446087196,"score_gpt":0.3381455200976736,"score_spread":0.3063590556368017,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}