{"id":"W2285127602","doi":"10.1111/cei.12735","title":"Pathogenic T helper type 17 cells contribute to type 1 diabetes independently of interleukin-22","year":2015,"lang":"en","type":"article","venue":"Clinical & Experimental Immunology","topic":"Diabetes and associated disorders","field":"Biochemistry, Genetics and Molecular Biology","cited_by":34,"is_retracted":false,"has_abstract":true,"ca_institutions":"Western University","funders":"Canadian Institutes of Health Research; Pfizer","keywords":"NOD mice; Interleukin 21; Immunology; Adoptive cell transfer; Nod; Interleukin 17; Interleukin 12; Biology; Interleukin 22; Interleukin 3; Pancreatic islets; Interleukin 4; Interleukin; Cytotoxic T cell; T cell; Cytokine; Antibody; Immune system; Endocrinology; Autoimmune disease; Diabetes mellitus; In vitro; Islet","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002789834,0.0007945313,0.0003087275,0.0003614264,0.0001858883,0.0004620285,0.0001755665,0.0002377166,0.002827396],"category_scores_gemma":[0.0003367829,0.0001686511,0.0003525993,0.0001558665,0.000346334,0.0002327854,0.0003368582,0.0008677618,0.000660158],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00009957361,"about_ca_system_score_gemma":0.0002292102,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001748645,"about_ca_topic_score_gemma":0.000269162,"domain_scores_codex":[0.9997343,0.00007743595,0.00002059007,0.00003219685,0.00005740963,0.00007793046],"domain_scores_gemma":[0.999679,0.00005638869,0.00006991206,0.00004083538,0.00004112282,0.0001127299],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.001554896,0.0002399424,0.009478698,0.0003425866,0.00004248997,0.002001182,0.0001364187,0.0002265768,0.9608892,0.00113103,0.0004233048,0.0235337],"study_design_scores_gemma":[0.00103651,0.006278416,0.1214665,0.0003967646,0.0006300138,0.01919645,0.0005426751,0.005044436,0.7614025,0.005576492,0.07835966,0.00006959495],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.968346,0.01574233,0.005162647,0.0005715282,0.0002649183,0.00009809159,0.0002624652,0.0001735096,0.009378497],"genre_scores_gemma":[0.9843871,0.008760226,0.002433064,0.0002051143,0.0002119212,0.00006471004,0.0001908093,0.0000283538,0.00371869],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002827396,"threshold_uncertainty_score":0.009458601,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02458505032461962,"score_gpt":0.3288666720109896,"score_spread":0.30428162168637,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}