{"id":"W2285433384","doi":"10.1002/glia.22973","title":"Toll‐like receptor‐mediated immune response inhibits prion propagation","year":2016,"lang":"en","type":"article","venue":"Glia","topic":"Prion Diseases and Protein Misfolding","field":"Biochemistry, Genetics and Molecular Biology","cited_by":22,"is_retracted":false,"has_abstract":true,"ca_institutions":"Women and Children’s Health Research Institute; University of Alberta","funders":"Alberta Prion Research Institute","keywords":"Biology; Innate immune system; Microglia; TLR2; Neuroinflammation; Immune system; Toll-like receptor; Neuroglia; Immunology; Tumor necrosis factor alpha; Interferon; Cell biology; Inflammation; Neuroscience; Central nervous system","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.000153938,0.0003290815,0.0002603837,0.0001278752,0.00009254381,0.0002206038,0.0001591869,0.0002517375,0.001249045],"category_scores_gemma":[0.0001267438,0.00006897013,0.0002176309,0.0000712194,0.000180749,0.0001832082,0.0001335314,0.0006815399,0.0003510937],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001075031,"about_ca_system_score_gemma":0.0001517858,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001371646,"about_ca_topic_score_gemma":0.0002724721,"domain_scores_codex":[0.9998928,0.00002726025,0.00001053652,0.0000165315,0.00001740659,0.00003550603],"domain_scores_gemma":[0.9999161,0.00001525183,0.00001663297,0.00001295389,0.00001442033,0.00002458564],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0004190311,0.0001241548,0.00008098563,0.00005674845,0.000005379575,0.00003580435,0.0000122444,0.00002965184,0.9975207,0.00006257738,0.00005011841,0.001602647],"study_design_scores_gemma":[0.0000679697,0.001847448,0.002173171,0.00001346751,0.00002149191,0.0002274624,0.00003493569,0.0006712064,0.9931149,0.00007234958,0.001752321,0.000003235079],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9943005,0.002282336,0.001657993,0.0001079044,0.00007093999,0.0000270865,0.000126191,0.00006169848,0.001365399],"genre_scores_gemma":[0.9959934,0.0008874346,0.001137909,0.0000610733,0.0000177786,0.00003362075,0.0002049135,0.000008251889,0.001655581],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001249045,"threshold_uncertainty_score":0.004178464,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.006426609276401323,"score_gpt":0.2268996246181587,"score_spread":0.2204730153417574,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}