{"id":"W2285433384","doi":"10.1002/glia.22973","title":"Toll‐like receptor‐mediated immune response inhibits prion propagation","year":2016,"lang":"en","type":"article","venue":"Glia","topic":"Prion Diseases and Protein Misfolding","field":"Biochemistry, Genetics and Molecular Biology","cited_by":22,"is_retracted":false,"has_abstract":true,"ca_institutions":"Women and Children’s Health Research Institute; University of Alberta","funders":"Alberta Prion Research Institute","keywords":"Biology; Innate immune system; Microglia; TLR2; Neuroinflammation; Immune system; Toll-like receptor; Neuroglia; Immunology; Tumor necrosis factor alpha; Interferon; Cell biology; Inflammation; Neuroscience; Central nervous system","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00029765,0.0001079106,0.00008214134,0.00003123413,0.00006764022,0.00001624553,0.0001106336,0.0001198882,0.0001369642],"category_scores_gemma":[0.0003590311,0.00007871651,0.0000646683,0.00006741629,0.00003772498,0.00000622766,0.00008220581,0.00003584213,0.0001443734],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0000244982,"about_ca_system_score_gemma":0.00008040055,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000003868241,"about_ca_topic_score_gemma":0.000001797219,"domain_scores_codex":[0.9991556,0.0001257502,0.0001669741,0.0002513627,0.0001118141,0.0001884859],"domain_scores_gemma":[0.9995005,0.00001919146,0.00007681355,0.0002770271,0.00004351156,0.00008293429],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.001000727,0.00002109623,0.0003098764,0.000006565879,0.00001262593,0.000001379837,0.00001321934,5.924337e-7,0.9601361,0.00001656137,0.002689121,0.03579211],"study_design_scores_gemma":[0.0006952457,0.0001891307,0.003868348,0.00004949962,0.000005156944,0.000003450944,0.000009744617,0.000004896135,0.7795269,0.00003132416,0.2154662,0.000150093],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9946879,0.002881353,0.0007513343,0.001084576,0.0002063879,0.0002466614,0.00003310285,0.00003154283,0.00007720722],"genre_scores_gemma":[0.9973593,0.0008622197,0.0002547024,0.0001546589,0.0001339699,0.00003195355,0.00008322555,0.0000177543,0.001102152],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.2127771,"threshold_uncertainty_score":0.3209966,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.006426609276401323,"score_gpt":0.2268996246181587,"score_spread":0.2204730153417574,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}