{"id":"W2285951030","doi":"10.1096/fasebj.23.1_supplement.675.4","title":"Crystal structure of histo‐aspartic protease (HAP) from <i>Plasmodium falciparum</i>","year":2009,"lang":"en","type":"article","venue":"The FASEB Journal","topic":"Malaria Research and Control","field":"Medicine","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Guelph","funders":"","keywords":"Pepstatin; Active site; Plasmodium falciparum; Chemistry; Protease; Proteases; Binding site; Serine protease; Biochemistry; Enzyme; Stereochemistry; Biology; Malaria","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001836231,0.0003482294,0.0003909986,0.0001507585,0.000301893,0.0004501649,0.0005348789,0.0003696725,0.00186648],"category_scores_gemma":[0.0003114185,0.0002147323,0.000178583,0.0003329987,0.0001341011,0.0002755948,0.0001285102,0.0009953305,0.000506313],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0005609494,"about_ca_system_score_gemma":0.0006558891,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.004585344,"about_ca_topic_score_gemma":0.004823094,"domain_scores_codex":[0.9999213,0.00001143412,0.000003810728,0.00001606624,0.00003622863,0.00001113935],"domain_scores_gemma":[0.999891,0.00002761594,0.00002460656,0.000003636313,0.00002671083,0.00002648502],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.002059882,0.0005304551,0.01122462,0.001659905,0.0002664489,0.001811229,0.0007482126,0.006965653,0.8903406,0.002676973,0.03674373,0.04497222],"study_design_scores_gemma":[0.002006624,0.001974339,0.2455494,0.0004380859,0.0006691646,0.00871021,0.001486468,0.1005466,0.3546376,0.002810649,0.2809175,0.0002533928],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9549651,0.01303894,0.004683947,0.001899072,0.0002416691,0.0001255986,0.008636449,0.0006298412,0.01577934],"genre_scores_gemma":[0.9241658,0.008647964,0.01778274,0.0005402981,0.00005146755,0.000138094,0.03815134,0.0002269878,0.01029535],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.004585344,"threshold_uncertainty_score":0.009117305,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01417233657538946,"score_gpt":0.2562395663228007,"score_spread":0.2420672297474112,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}