{"id":"W2285959938","doi":"10.1093/ijnp/pyv108","title":"Methadone Reverses Analgesic Tolerance Induced by Morphine Pretreatment","year":2015,"lang":"en","type":"article","venue":"The International Journal of Neuropsychopharmacology","topic":"Receptor Mechanisms and Signaling","field":"Biochemistry, Genetics and Molecular Biology","cited_by":24,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"Institute of Genetics; Centre National de la Recherche Scientifique; Université de Strasbourg; Institut National de la Santé et de la Recherche Médicale","keywords":"Morphine; Pharmacology; μ-opioid receptor; Drug tolerance; Agonist; Opioid; Analgesic; Chemistry; DAMGO; Methadone; Opiate; Enkephalin; Receptor; Opioid receptor; Medicine; Internal medicine","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00005513206,0.0002350758,0.0002031602,0.0001696036,0.00009497365,0.0001056118,0.0002433015,0.0001701147,0.002232955],"category_scores_gemma":[0.0001304252,0.00008607737,0.0001490163,0.00006737576,0.0001500014,0.000137709,0.0001104549,0.0008036202,0.0002527903],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001340047,"about_ca_system_score_gemma":0.0002300057,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0005028812,"about_ca_topic_score_gemma":0.00135536,"domain_scores_codex":[0.9999288,0.000007274542,0.000005425446,0.000009123328,0.00002820391,0.000021088],"domain_scores_gemma":[0.9998778,0.00001052845,0.00004126045,0.00001223058,0.00001803827,0.00004011751],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0006777518,0.0003565801,0.0005052674,0.0001360176,0.00001256699,0.00009791926,0.00003863218,0.00005152474,0.9909979,0.0001013922,0.0001223602,0.006902108],"study_design_scores_gemma":[0.0003378489,0.01344482,0.04058334,0.00009418911,0.00007147634,0.0008323794,0.0001713277,0.001220998,0.9362689,0.0001359108,0.00682237,0.00001643169],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9956126,0.002100596,0.0005202273,0.0001181352,0.00004599217,0.00004969759,0.0001699986,0.00007068222,0.001311901],"genre_scores_gemma":[0.9943527,0.001476768,0.0007457011,0.00008517194,0.00001918979,0.00004414946,0.0002296793,0.00001061898,0.003035962],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002232955,"threshold_uncertainty_score":0.007470012,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02972771475800848,"score_gpt":0.3159558296152032,"score_spread":0.2862281148571947,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}