{"id":"W2286149763","doi":"10.1155/2016/7678901","title":"Characterization of IXINITY® (Trenonacog Alfa), a Recombinant Factor IX with Primary Sequence Corresponding to the Threonine-148 Polymorph","year":2016,"lang":"en","type":"article","venue":"Advances in Hematology","topic":"Hemophilia Treatment and Research","field":"Medicine","cited_by":18,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Manitoba; Emergent BioSolutions (Canada)","funders":"University of Nebraska-Lincoln","keywords":"Recombinant DNA; Glycosylation; Factor IX; Threonine; Factor IXa; Chromatography; Molecular biology; Size-exclusion chromatography; Factor X; Biochemistry; Medicine; Chemistry; Phosphorylation; Serine; Biology; Platelet; Internal medicine","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00018033,0.0002509567,0.0001296641,0.0001847351,0.00008749966,0.0001980405,0.000126374,0.0001252894,0.0007061216],"category_scores_gemma":[0.0002540665,0.00006933282,0.0001636021,0.0001269532,0.0001307227,0.0001329571,0.00009445594,0.0002356968,0.0003656519],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002153885,"about_ca_system_score_gemma":0.000169033,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000628429,"about_ca_topic_score_gemma":0.0004744165,"domain_scores_codex":[0.9999064,0.00001076187,0.00000838676,0.00002073143,0.00004070197,0.00001312285],"domain_scores_gemma":[0.9999177,0.00001429861,0.00002625572,0.000007965285,0.00001829286,0.00001552795],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00005382713,0.00001184653,0.0003548441,0.0000166544,0.000003452321,0.00006588613,0.00001611665,0.00008117383,0.9973162,0.00003750421,0.0000237879,0.002018781],"study_design_scores_gemma":[0.0000231146,0.0009638881,0.01238661,0.00001242635,0.00002691727,0.001871531,0.00004358846,0.0008489215,0.9724135,0.00005869855,0.01134357,0.000007356598],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9931796,0.001190282,0.003817206,0.00004215059,0.00001062106,0.00006529861,0.0003502614,0.00001866321,0.001325974],"genre_scores_gemma":[0.9810254,0.001378127,0.009065169,0.00008328957,0.00001532284,0.00005018836,0.003727181,0.0000453571,0.004609926],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0007061216,"threshold_uncertainty_score":0.002362251,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02883651409119573,"score_gpt":0.3233519393056755,"score_spread":0.2945154252144798,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}