{"id":"W2286249317","doi":"10.1016/j.trci.2015.12.003","title":"First in human study with a prodrug of galantamine: Improved benefit‐risk ratio?","year":2016,"lang":"en","type":"article","venue":"Alzheimer s & Dementia Translational Research & Clinical Interventions","topic":"Chemical synthesis and alkaloids","field":"Chemistry","cited_by":23,"is_retracted":false,"has_abstract":true,"ca_institutions":"Health PEI; University of Prince Edward Island","funders":"","keywords":"Galantamine; Cholinesterase; Pharmacology; Tolerability; Prodrug; Placebo; Pharmacokinetics; Drug; Pharmacodynamics; Donepezil; Medicine; Internal medicine; Adverse effect","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001882197,0.001064692,0.002253389,0.0002745308,0.0002696326,0.0007779759,0.0004680211,0.001552604,0.00920285],"category_scores_gemma":[0.00179098,0.0003870815,0.001551204,0.0002024417,0.0005928082,0.0006093261,0.0002298571,0.001378213,0.001470109],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0005663905,"about_ca_system_score_gemma":0.0005347563,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0003337191,"about_ca_topic_score_gemma":0.0005405904,"domain_scores_codex":[0.9994208,0.00029184,0.00004233548,0.0001314094,0.0000509459,0.0000627771],"domain_scores_gemma":[0.9992127,0.000260541,0.0001632604,0.0001504441,0.00006133748,0.0001516188],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"nonrandomized_trial","study_design_scores_codex":[0.8557331,0.01398932,0.00291239,0.00113981,0.002138566,0.0004792483,0.00008899054,0.0005695905,0.05920217,0.0003365772,0.002096383,0.06131382],"study_design_scores_gemma":[0.2106137,0.7463762,0.007795194,0.00008283262,0.002971809,0.0007426863,0.00004111119,0.001003607,0.02263573,0.000486202,0.007195659,0.0000553458],"study_design_candidate":"nonrandomized_trial","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9758906,0.009070882,0.003924706,0.0008270912,0.0005402014,0.003451883,0.002057562,0.0002575664,0.003979598],"genre_scores_gemma":[0.9887834,0.002703701,0.00201047,0.0005748305,0.00034323,0.001113047,0.0008864008,0.00003614014,0.003548821],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.00920285,"threshold_uncertainty_score":0.03078657,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.1542490926533338,"score_gpt":0.4401706929065102,"score_spread":0.2859216002531765,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}