{"id":"W2286693725","doi":"10.1158/1078-0432.ccr-15-2499","title":"Relationship between Tumor Biomarkers and Efficacy in EMILIA, a Phase III Study of Trastuzumab Emtansine in HER2-Positive Metastatic Breast Cancer","year":2016,"lang":"en","type":"article","venue":"Clinical Cancer Research","topic":"HER2/EGFR in Cancer Research","field":"Medicine","cited_by":226,"is_retracted":false,"has_abstract":true,"ca_institutions":"Sunnybrook Health Science Centre","funders":"National Cancer Institute","keywords":"Lapatinib; Trastuzumab emtansine; Trastuzumab; Capecitabine; Medicine; Cancer; Breast cancer; Metastatic breast cancer; Biomarker; Cancer research; Oncology; PTEN; Antibody-drug conjugate; Internal medicine; Antibody; Immunology; Biology; Monoclonal antibody; Apoptosis; Colorectal cancer","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.008415799,0.0002652148,0.001192409,0.0009680408,0.000103433,0.00002651932,0.0003581356,0.0001546754,0.0005441614],"category_scores_gemma":[0.00437605,0.0001912407,0.0001159093,0.002354699,0.001264873,0.0001586126,0.0002609221,0.001521084,0.00001620551],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.001249403,"about_ca_system_score_gemma":0.002491341,"about_ca_topic_candidate":true,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.01761047,"about_ca_topic_score_gemma":0.01388873,"domain_scores_codex":[0.9923195,0.002375557,0.001695303,0.001021085,0.001611416,0.0009771285],"domain_scores_gemma":[0.9884327,0.009506914,0.0001777556,0.0006601968,0.0006249463,0.000597459],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.007765549,0.004392078,0.9123875,0.0002564904,0.0001990827,0.0003963962,0.001171668,0.000001963738,0.0004240517,0.00001255245,0.0005464008,0.0724462],"study_design_scores_gemma":[0.04136972,0.003565803,0.9510526,0.001903464,0.00009412418,0.00001263361,0.001373765,0.00004057004,0.0001987887,0.000109602,0.00008933609,0.0001895933],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9885116,0.001175161,0.00001033296,0.006490627,0.00008553887,0.003188279,0.0003534703,0.00002018746,0.0001648704],"genre_scores_gemma":[0.9980296,0.0005973841,0.00004928396,0.00005921486,0.0002337635,0.0006725315,0.000008703526,0.00006162274,0.0002879092],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0722566,"threshold_uncertainty_score":0.9889314,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.3463970865185873,"score_gpt":0.593692150892299,"score_spread":0.2472950643737117,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}