{"id":"W2286693725","doi":"10.1158/1078-0432.ccr-15-2499","title":"Relationship between Tumor Biomarkers and Efficacy in EMILIA, a Phase III Study of Trastuzumab Emtansine in HER2-Positive Metastatic Breast Cancer","year":2016,"lang":"en","type":"article","venue":"Clinical Cancer Research","topic":"HER2/EGFR in Cancer Research","field":"Medicine","cited_by":226,"is_retracted":false,"has_abstract":true,"ca_institutions":"Sunnybrook Health Science Centre","funders":"National Cancer Institute","keywords":"Lapatinib; Trastuzumab emtansine; Trastuzumab; Capecitabine; Medicine; Cancer; Breast cancer; Metastatic breast cancer; Biomarker; Cancer research; Oncology; PTEN; Antibody-drug conjugate; Internal medicine; Antibody; Immunology; Biology; Monoclonal antibody; Apoptosis; Colorectal cancer","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.002444533,0.0006976092,0.0008823028,0.0004749048,0.0002259047,0.0005501644,0.000582456,0.000502095,0.0009019382],"category_scores_gemma":[0.001075987,0.0002644019,0.0006423867,0.0003688935,0.0003705616,0.0003551502,0.0002591387,0.001408428,0.0002973798],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0008415784,"about_ca_system_score_gemma":0.0007602626,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0004036003,"about_ca_topic_score_gemma":0.001543944,"domain_scores_codex":[0.9994416,0.0003140238,0.00002973627,0.00006369069,0.00007669051,0.00007415956],"domain_scores_gemma":[0.9990395,0.0001571501,0.0003512017,0.0000874863,0.00007451652,0.0002900506],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"meta_analysis","study_design_scores_codex":[0.413457,0.05901277,0.1725354,0.001028403,0.002990694,0.0004005449,0.0004678109,0.005306913,0.1474834,0.0002642678,0.004560035,0.1924927],"study_design_scores_gemma":[0.08557031,0.4457884,0.4244395,0.00008354282,0.001739621,0.000893585,0.0001140463,0.003500733,0.03183141,0.0001109882,0.005865616,0.00006222857],"study_design_candidate":"meta_analysis","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9969909,0.001070529,0.0001580929,0.0001358751,0.00001354015,0.0003667425,0.0003392349,0.00002677832,0.0008982356],"genre_scores_gemma":[0.9948656,0.0006562418,0.0009707685,0.0004544074,0.00005138647,0.0003523191,0.001704174,0.00001153016,0.0009335656],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002444533,"threshold_uncertainty_score":0.01292807,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.3463970865185873,"score_gpt":0.593692150892299,"score_spread":0.2472950643737117,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}