{"id":"W2287036964","doi":"10.1021/acscentsci.5b00399","title":"Potent Human α-Amylase Inhibition by the β-Defensin-like Protein Helianthamide","year":2016,"lang":"en","type":"article","venue":"ACS Central Science","topic":"Protein Hydrolysis and Bioactive Peptides","field":"Biochemistry, Genetics and Molecular Biology","cited_by":41,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of British Columbia; Canada's Michael Smith Genome Sciences Centre","funders":"SLAC National Accelerator Laboratory; Basic Energy Sciences; National Institute of General Medical Sciences; Biological and Environmental Research; Natural Sciences and Engineering Research Council of Canada; Canada Research Chairs; Office of Science; National Institutes of Health; Canadian Institutes of Health Research; Universidade de São Paulo; U.S. Department of Energy","keywords":"Defensin; Amylase; Escherichia coli; Biology; Biochemistry; Chemistry; Peptide; Enzyme; Gene","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003623168,0.0001302754,0.000076444,0.00002464391,0.0004018647,0.00006489523,0.0003212124,0.00005744134,0.0000187455],"category_scores_gemma":[0.00008616879,0.00006653355,0.00005868877,0.0001875322,0.000843496,0.0000198937,0.0001750043,0.00005297732,0.00002149133],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00004625119,"about_ca_system_score_gemma":0.00007194615,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00009024149,"about_ca_topic_score_gemma":0.00003644598,"domain_scores_codex":[0.9985657,0.000047568,0.0001475361,0.000438667,0.0003086164,0.0004919009],"domain_scores_gemma":[0.9993552,0.000005152937,0.00008266505,0.0003458,0.0000826523,0.0001285176],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0000141854,0.00003847705,0.0004351185,0.000001615026,0.00000543634,0.000001663426,0.000009992651,9.457717e-7,0.9925128,0.0001831596,0.0013599,0.00543674],"study_design_scores_gemma":[0.0002179931,0.0001383127,0.00456539,0.00002508417,0.000004782658,0.000008555401,0.0000181703,0.000003641623,0.9851192,0.0001594149,0.00959916,0.0001402987],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9965299,0.0001661843,0.0005176217,0.001984892,0.00007113053,0.0003107605,0.00002585179,0.00001338989,0.0003802814],"genre_scores_gemma":[0.9982418,0.00004124934,0.00006601189,0.0004024732,0.0001144362,0.00002568462,0.00001189983,0.000007811987,0.001088642],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.008239261,"threshold_uncertainty_score":0.3107896,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.00757509671408073,"score_gpt":0.2299415520085394,"score_spread":0.2223664552944587,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}