{"id":"W2287036964","doi":"10.1021/acscentsci.5b00399","title":"Potent Human α-Amylase Inhibition by the β-Defensin-like Protein Helianthamide","year":2016,"lang":"en","type":"article","venue":"ACS Central Science","topic":"Protein Hydrolysis and Bioactive Peptides","field":"Biochemistry, Genetics and Molecular Biology","cited_by":41,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of British Columbia; Canada's Michael Smith Genome Sciences Centre","funders":"SLAC National Accelerator Laboratory; Basic Energy Sciences; National Institute of General Medical Sciences; Biological and Environmental Research; Natural Sciences and Engineering Research Council of Canada; Canada Research Chairs; Office of Science; National Institutes of Health; Canadian Institutes of Health Research; Universidade de São Paulo; U.S. Department of Energy","keywords":"Defensin; Amylase; Escherichia coli; Biology; Biochemistry; Chemistry; Peptide; Enzyme; Gene","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001022156,0.0002514993,0.0001601033,0.0001076992,0.00006832982,0.0002066166,0.0001430936,0.000168659,0.00111953],"category_scores_gemma":[0.00006467338,0.0001023276,0.0001234949,0.00009100949,0.000105431,0.0001176813,0.0001584673,0.0003037091,0.0003730872],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001229301,"about_ca_system_score_gemma":0.0001024201,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002507427,"about_ca_topic_score_gemma":0.0004041745,"domain_scores_codex":[0.99994,0.00000958287,0.000005425803,0.00001147029,0.00001926511,0.00001407806],"domain_scores_gemma":[0.9999672,0.000009074104,0.000007106693,0.000003484816,0.00000384199,0.000009225802],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00004473208,0.000007364828,0.00002616425,0.00001097302,0.000001869464,0.0000167884,0.000004060578,0.00001947831,0.9992064,0.00001701399,0.00002614218,0.0006190126],"study_design_scores_gemma":[0.00001087793,0.0001668554,0.0008526642,0.000001665911,0.000003072679,0.00007968819,0.000007047063,0.0002313956,0.9974305,0.00001152419,0.001203203,0.000001501517],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9886525,0.002477034,0.004340927,0.0001116608,0.00002769265,0.00003742437,0.0004800124,0.0001151611,0.003757638],"genre_scores_gemma":[0.9857455,0.002437601,0.004761633,0.0001107663,0.00001345022,0.00004154533,0.001171869,0.00003247093,0.005685165],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.00111953,"threshold_uncertainty_score":0.003745198,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.00757509671408073,"score_gpt":0.2299415520085394,"score_spread":0.2223664552944587,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}