{"id":"W2287114519","doi":"10.1074/jbc.m115.684308","title":"Protein Kinase C ζ Interacts with a Novel Binding Region of Gαq to Act as a Functional Effector","year":2016,"lang":"en","type":"article","venue":"Journal of Biological Chemistry","topic":"Receptor Mechanisms and Signaling","field":"Biochemistry, Genetics and Molecular Biology","cited_by":10,"is_retracted":false,"has_abstract":true,"ca_institutions":"Université de Montréal","funders":"Office of Extramural Research, National Institutes of Health; National Institute of General Medical Sciences; European Regional Development Fund; National Institutes of Health; Consejería de Sanidad, Comunidad de Madrid; Canadian HIV Trials Network, Canadian Institutes of Health Research; European Commission; Instituto de Salud Carlos III; Canadian Institutes of Health Research; Comunidad de Madrid; Fundación Ramón Areces","keywords":"Heterotrimeric G protein; G protein-coupled receptor; Effector; Protein kinase C; Cell biology; G protein-coupled receptor kinase; Biology; Signal transduction; G protein; Scaffold protein; Gq alpha subunit; G beta-gamma complex; Chemistry","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001966953,0.0004651536,0.0002129704,0.0001838936,0.0002910313,0.0003304553,0.0003490153,0.0003979306,0.001105987],"category_scores_gemma":[0.0001702145,0.0001666523,0.0003920726,0.0001863924,0.0003125205,0.0002099864,0.0003554244,0.0004383787,0.0007392453],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0008377268,"about_ca_system_score_gemma":0.0003019975,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001117325,"about_ca_topic_score_gemma":0.001040582,"domain_scores_codex":[0.9998401,0.00003497466,0.00001114704,0.00003110004,0.00004245338,0.00004012595],"domain_scores_gemma":[0.9999225,0.00001153875,0.00002364589,0.00001290542,0.000007716606,0.00002168981],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001528836,0.00002545456,0.0002372801,0.00001625803,0.000007961327,0.0001610783,0.000009223269,0.000105818,0.9982864,0.0003163278,0.00002571149,0.0006555212],"study_design_scores_gemma":[0.0001324671,0.0002727876,0.0146948,0.00001599373,0.00003888711,0.001665935,0.00003643399,0.003129252,0.97369,0.0004419342,0.005866526,0.00001502551],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9934725,0.001245854,0.003938383,0.0001568694,0.00002979297,0.00002757413,0.00007760536,0.00003765506,0.001013775],"genre_scores_gemma":[0.9968258,0.0004105603,0.001526861,0.00007998513,0.00001125649,0.00001169227,0.0001781717,0.000008322401,0.0009472842],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001117325,"threshold_uncertainty_score":0.006078184,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02090648640222365,"score_gpt":0.2420566211828856,"score_spread":0.2211501347806619,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}