{"id":"W2287115125","doi":"10.1038/srep19725","title":"TCTP contains a BH3-like domain, which instead of inhibiting, activates Bcl-xL","year":2016,"lang":"en","type":"article","venue":"Scientific Reports","topic":"Cancer, Stress, Anesthesia, and Immune Response","field":"Medicine","cited_by":45,"is_retracted":false,"has_abstract":true,"ca_institutions":"McMaster University; University of Toronto; Sunnybrook Health Science Centre","funders":"French Infrastructure for Integrated Structural Biology; Ciência sem Fronteiras; Universidade Federal do Paraná; Servier; Université de Strasbourg; Institut National de la Santé et de la Recherche Médicale; Institut National Du Cancer; Coordenação de Aperfeiçoamento de Pessoal de Nível Superior; Conselho Nacional de Desenvolvimento Científico e Tecnológico; European Synchrotron Radiation Facility; CHIST-ERA; Agence Nationale de la Recherche; Laboratoire d'Excellence en Recherche sur le Médicament et l'Innovation Thérapeutique; Centre National de la Recherche Scientifique; European Molecular Biology Laboratory; European Commission; Canadian Institutes of Health Research; Association pour la Recherche sur le Cancer","keywords":"Bcl-xL; Apoptosis; Function (biology); Cell biology; In vitro; Chemistry; In vivo; Biology; Computational biology; Biophysics; Biochemistry; Genetics; Programmed cell death","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00141139,0.0002228443,0.0005148096,0.0003251871,0.0002225414,0.00007084943,0.0001204753,0.0001253215,0.0003198427],"category_scores_gemma":[0.0007667815,0.0001486618,0.0001981465,0.0006474221,0.0005932326,0.0002324902,0.00007964752,0.0001296356,0.00003690557],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001370913,"about_ca_system_score_gemma":0.000797184,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001403064,"about_ca_topic_score_gemma":0.0001182729,"domain_scores_codex":[0.997175,0.00008364839,0.0008108041,0.0007331309,0.0007289676,0.0004684752],"domain_scores_gemma":[0.9973757,0.0001200189,0.0006021755,0.001125919,0.0005741387,0.0002020767],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"not_applicable","study_design_scores_codex":[0.0006592979,0.0003066285,0.03219652,0.0001415051,0.00009330417,0.0006165644,0.001322377,7.616491e-7,0.915215,0.00009545492,0.0333442,0.01600839],"study_design_scores_gemma":[0.001801122,0.0002950314,0.01924216,0.001478789,0.00008533438,0.002576061,0.0009764734,0.000003407142,0.4347987,0.0009697263,0.5374413,0.0003319107],"study_design_candidate":"bench_or_experimental","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9889427,0.0008103724,0.00005857751,0.00129499,0.00283574,0.0004892319,0.000005934649,0.00008983612,0.005472585],"genre_scores_gemma":[0.9770609,0.00007285752,0.0001659992,0.00008332051,0.0002104081,0.00002695339,0.00002264632,0.00003175605,0.02232517],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.5040971,"threshold_uncertainty_score":0.606225,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01212566508189118,"score_gpt":0.2562162852668124,"score_spread":0.2440906201849213,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}