{"id":"W2287115125","doi":"10.1038/srep19725","title":"TCTP contains a BH3-like domain, which instead of inhibiting, activates Bcl-xL","year":2016,"lang":"en","type":"article","venue":"Scientific Reports","topic":"Cancer, Stress, Anesthesia, and Immune Response","field":"Medicine","cited_by":45,"is_retracted":false,"has_abstract":true,"ca_institutions":"McMaster University; University of Toronto; Sunnybrook Health Science Centre","funders":"French Infrastructure for Integrated Structural Biology; Ciência sem Fronteiras; Universidade Federal do Paraná; Servier; Université de Strasbourg; Institut National de la Santé et de la Recherche Médicale; Institut National Du Cancer; Coordenação de Aperfeiçoamento de Pessoal de Nível Superior; Conselho Nacional de Desenvolvimento Científico e Tecnológico; European Synchrotron Radiation Facility; CHIST-ERA; Agence Nationale de la Recherche; Laboratoire d'Excellence en Recherche sur le Médicament et l'Innovation Thérapeutique; Centre National de la Recherche Scientifique; European Molecular Biology Laboratory; European Commission; Canadian Institutes of Health Research; Association pour la Recherche sur le Cancer","keywords":"Bcl-xL; Apoptosis; Function (biology); Cell biology; In vitro; Chemistry; In vivo; Biology; Computational biology; Biophysics; Biochemistry; Genetics; Programmed cell death","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00007607004,0.0002030867,0.0001529982,0.0001333815,0.0002723558,0.0002999078,0.000195838,0.0002559439,0.00213213],"category_scores_gemma":[0.0001322351,0.00007873938,0.0002574884,0.0002210222,0.0002591758,0.0002972001,0.0002064339,0.0004901486,0.0006232267],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002617986,"about_ca_system_score_gemma":0.0002455106,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000510858,"about_ca_topic_score_gemma":0.0005345976,"domain_scores_codex":[0.9999113,0.00001262156,0.000007007461,0.000015916,0.00002993178,0.00002315608],"domain_scores_gemma":[0.9998001,0.00003441358,0.00006074801,0.00003014808,0.00002249495,0.00005201244],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001266386,0.00001998384,0.0008505944,0.00005662766,0.000009609315,0.0001597542,0.00002102183,0.00003541357,0.9953111,0.0001877373,0.00007776322,0.003143873],"study_design_scores_gemma":[0.00003892456,0.0005329383,0.01131188,0.000009107815,0.00003327674,0.004941907,0.00005482567,0.0004303592,0.9696797,0.0001861402,0.01277047,0.00001039784],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.98467,0.00311593,0.008321879,0.0002259267,0.00004844393,0.00004402855,0.0004574395,0.0001792301,0.002937029],"genre_scores_gemma":[0.994426,0.0006879852,0.002495014,0.00006347583,0.00002166172,0.000018331,0.0007992242,0.00001598977,0.001472167],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.00213213,"threshold_uncertainty_score":0.007132649,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01212566508189118,"score_gpt":0.2562162852668124,"score_spread":0.2440906201849213,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}