{"id":"W2287232851","doi":"10.1371/journal.pone.0149177","title":"Jagn1 Is Induced in Response to ER Stress and Regulates Proinsulin Biosynthesis","year":2016,"lang":"en","type":"article","venue":"PLoS ONE","topic":"Endoplasmic Reticulum Stress and Disease","field":"Biochemistry, Genetics and Molecular Biology","cited_by":14,"is_retracted":false,"has_abstract":true,"ca_institutions":"St. Michael's Hospital; University of British Columbia; University of Toronto","funders":"Banting and Best Diabetes Centre, University of Toronto; Natural Sciences and Engineering Research Council of Canada; Canadian Institutes of Health Research","keywords":"Proinsulin; Insulinoma; Unfolded protein response; Biosynthesis; Prohormone; Insulin; Protein biosynthesis; Secretion; Internal medicine; Glucose homeostasis; Endocrinology; Biology; Cell biology; Chemistry; Biochemistry; Hormone; Medicine; Insulin resistance; Endoplasmic reticulum; Enzyme","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.000122857,0.000292213,0.0002791188,0.0002790763,0.0001722429,0.0004221105,0.0001445078,0.0003693397,0.000867585],"category_scores_gemma":[0.000128231,0.0001523126,0.0002805015,0.0001833127,0.0002096523,0.000252037,0.0002401696,0.0005876562,0.0004051037],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003421799,"about_ca_system_score_gemma":0.0001385379,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000202728,"about_ca_topic_score_gemma":0.0003332476,"domain_scores_codex":[0.9999082,0.000007954976,0.000007931961,0.00003200168,0.00002056806,0.00002321912],"domain_scores_gemma":[0.9998553,0.0000161196,0.00004671047,0.00001402872,0.00001777272,0.00005007141],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00007197068,0.000004351616,0.0002776294,0.00002326991,0.000002349041,0.00005817779,0.000006054373,0.00001527691,0.9991618,0.00002147387,0.00002478633,0.0003327897],"study_design_scores_gemma":[0.00001635215,0.0001182752,0.05516559,0.00001689996,0.00002495965,0.001234008,0.00007196324,0.0009547843,0.9384758,0.0001563784,0.00375372,0.00001132725],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9928145,0.002749198,0.00246878,0.0002680726,0.00006838959,0.00001336596,0.0006479163,0.0001165916,0.0008531226],"genre_scores_gemma":[0.9892005,0.001751181,0.002968357,0.0002386105,0.00002402006,0.00002387246,0.001981884,0.00004672121,0.003764913],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.000867585,"threshold_uncertainty_score":0.002902329,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01864529662708289,"score_gpt":0.2269972052693225,"score_spread":0.2083519086422397,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}