{"id":"W2287650212","doi":"10.1021/acsnano.5b07102","title":"Enzyme-Powered Three-Dimensional DNA Nanomachine for DNA Walking, Payload Release, and Biosensing","year":2016,"lang":"en","type":"article","venue":"ACS Nano","topic":"Advanced biosensing and bioanalysis techniques","field":"Biochemistry, Genetics and Molecular Biology","cited_by":365,"is_retracted":false,"has_abstract":true,"ca_institutions":"Brock University","funders":"Brock University; Natural Sciences and Engineering Research Council of Canada; Government of Canada","keywords":"Payload (computing); Biosensor; Nanotechnology; DNA; Enzyme; Biophysics; Materials science; Chemistry; Computer science; Biology; Biochemistry; Computer network","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001730649,0.0003417123,0.0002619475,0.0001817685,0.0001548305,0.0003118867,0.0004632414,0.0005303412,0.0004136476],"category_scores_gemma":[0.000345821,0.0002291044,0.0002215076,0.0001666834,0.0003192322,0.0004595067,0.000418338,0.0005359984,0.0003248518],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002649318,"about_ca_system_score_gemma":0.000224232,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001865126,"about_ca_topic_score_gemma":0.0004667424,"domain_scores_codex":[0.999835,0.00001883353,0.00001180668,0.00004518732,0.00007270312,0.00001642725],"domain_scores_gemma":[0.9998528,0.00005161457,0.00003025792,0.00001984166,0.00002014313,0.00002529436],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00001324691,0.00001113729,0.0000833696,0.00006829445,0.000003225203,0.0000449057,0.0000267826,0.0003105507,0.9939743,0.0005428206,0.00005924008,0.004862178],"study_design_scores_gemma":[0.000003525459,0.00003189527,0.0001219395,0.00000206135,0.000002308439,0.00009603673,0.000004334669,0.001439034,0.9958015,0.00009412263,0.002395216,0.000008006996],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.6874979,0.007440074,0.2975367,0.0004326599,0.0003997857,0.0001943634,0.0003508572,0.0009750216,0.005172551],"genre_scores_gemma":[0.7850005,0.002011005,0.2079224,0.000206398,0.00003769711,0.0001746246,0.0002314045,0.00007207278,0.004343877],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0005303412,"threshold_uncertainty_score":0.00192219,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.008208282233540443,"score_gpt":0.2492647344532266,"score_spread":0.2410564522196862,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}