{"id":"W2287794423","doi":"10.1186/s13058-016-0675-7","title":"Genetic predisposition to ductal carcinoma in situ of the breast","year":2016,"lang":"en","type":"article","venue":"Breast Cancer Research","topic":"BRCA gene mutations in cancer","field":"Biochemistry, Genetics and Molecular Biology","cited_by":64,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Toronto; University Health Network; Lunenfeld-Tanenbaum Research Institute; Mount Sinai Hospital; Centre hospitalier de l'Université Laval; Centre hospitalier universitaire de Québec; Université Laval; McGill Genome Centre; McGill University; McGill University and Génome Québec Innovation Centre","funders":"Division of Cancer Epidemiology and Genetics, National Cancer Institute; Medical Research and Materiel Command; Cancer Council NSW; National Health and Medical Research Council; Medical Research Council; U.S. Army; Agence Nationale de Sécurité Sanitaire de l’Alimentation, de l’Environnement et du Travail; Institut National Du Cancer; Deutsche Krebshilfe; Sundhed og Sygdom, Det Frie Forskningsråd; Universitetet i Oslo; Karolinska Institutet; Haukeland Universitetssjukehus; Deutsche Gesetzliche Unfallversicherung; Nederlandse Organisatie voor Wetenschappelijk Onderzoek; Cancer Council Victoria; University of Melbourne; Bundesministerium für Bildung und Forschung; Ovarian Cancer Research Fund; Agence Nationale de la Recherche; Cancer Australia; National Breast Cancer Foundation; King's College London; Roswell Park Cancer Institute; National Institute for Health and Care Research; McGill University; Breast Cancer Research Foundation; University of Cambridge; KWF Kankerbestrijding; Herlev Hospital; Wellcome Trust; U.S. Department of Defense; Cancer Research UK; Canadian Institutes of Health Research; Cancer Council South Australia; Fonds Wetenschappelijk Onderzoek; National Cancer Institute; Cancer Institute NSW; London School of Hygiene and Tropical Medicine; NIHR Biomedical Research Centre, Royal Marsden NHS Foundation Trust/Institute of Cancer Research; Fondation de France; Breast Cancer Campaign; Akershus Universitetssykehus; Centre Hospitalier Universitaire de Québec; Université Laval; Cancer Council Tasmania; Francis Crick Institute; National Institutes of Health; David F. and Margaret T. Grohne Family Foundation; Helsingin ja Uudenmaan Sairaanhoitopiiri; Medisinske fakultet, Universitetet i Oslo; Ligue Contre le Cancer; Deutsches Krebsforschungszentrum; Universitetet i Bergen; Génome Québec; Associazione Italiana per la Ricerca sul Cancro","keywords":"Surgical oncology; Ductal carcinoma; Breast cancer; Medicine; Genetic predisposition; Oncology; Internal medicine; Cancer; Disease","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0008225588,0.0004324643,0.0004962154,0.00121857,0.0003901368,0.0005426619,0.0003532813,0.0005537001,0.006253283],"category_scores_gemma":[0.00226893,0.0001786468,0.0005507168,0.001730434,0.0003815385,0.0001777282,0.0004654881,0.0004070208,0.0003219186],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002108441,"about_ca_system_score_gemma":0.000272628,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001361147,"about_ca_topic_score_gemma":0.001192017,"domain_scores_codex":[0.9992113,0.0001896844,0.0001004825,0.0002947176,0.0001196258,0.00008418647],"domain_scores_gemma":[0.9985188,0.0006403284,0.000484106,0.0001514799,0.00008675594,0.0001185872],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.0004545924,0.00005950769,0.9806746,0.0002235314,0.0009507583,0.001442542,0.0001809567,0.0002013737,0.008006783,0.0002802594,0.0003399313,0.007185124],"study_design_scores_gemma":[0.00003695428,0.0001618403,0.9886369,0.00008798972,0.0008188298,0.006531431,0.0001523573,0.0001837478,0.001269662,0.0004293537,0.001679289,0.00001165266],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9938812,0.002074869,0.0009214638,0.0001332147,0.00003865881,0.0000378045,0.0009797409,0.00003539374,0.001897579],"genre_scores_gemma":[0.9982229,0.0004972091,0.0004407386,0.00005088256,0.00003694238,0.00001357879,0.0004626226,0.000006073058,0.0002691287],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.006253283,"threshold_uncertainty_score":0.02091926,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01978692992831823,"score_gpt":0.3301965563032143,"score_spread":0.3104096263748961,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). 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