{"id":"W2287794423","doi":"10.1186/s13058-016-0675-7","title":"Genetic predisposition to ductal carcinoma in situ of the breast","year":2016,"lang":"en","type":"article","venue":"Breast Cancer Research","topic":"BRCA gene mutations in cancer","field":"Biochemistry, Genetics and Molecular Biology","cited_by":64,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Toronto; University Health Network; Lunenfeld-Tanenbaum Research Institute; Mount Sinai Hospital; Centre hospitalier de l'Université Laval; Centre hospitalier universitaire de Québec; Université Laval; McGill Genome Centre; McGill University; McGill University and Génome Québec Innovation Centre","funders":"Division of Cancer Epidemiology and Genetics, National Cancer Institute; Medical Research and Materiel Command; Cancer Council NSW; National Health and Medical Research Council; Medical Research Council; U.S. Army; Agence Nationale de Sécurité Sanitaire de l’Alimentation, de l’Environnement et du Travail; Institut National Du Cancer; Deutsche Krebshilfe; Sundhed og Sygdom, Det Frie Forskningsråd; Universitetet i Oslo; Karolinska Institutet; Haukeland Universitetssjukehus; Deutsche Gesetzliche Unfallversicherung; Nederlandse Organisatie voor Wetenschappelijk Onderzoek; Cancer Council Victoria; University of Melbourne; Bundesministerium für Bildung und Forschung; Ovarian Cancer Research Fund; Agence Nationale de la Recherche; Cancer Australia; National Breast Cancer Foundation; King's College London; Roswell Park Cancer Institute; National Institute for Health and Care Research; McGill University; Breast Cancer Research Foundation; University of Cambridge; KWF Kankerbestrijding; Herlev Hospital; Wellcome Trust; U.S. Department of Defense; Cancer Research UK; Canadian Institutes of Health Research; Cancer Council South Australia; Fonds Wetenschappelijk Onderzoek; National Cancer Institute; Cancer Institute NSW; London School of Hygiene and Tropical Medicine; NIHR Biomedical Research Centre, Royal Marsden NHS Foundation Trust/Institute of Cancer Research; Fondation de France; Breast Cancer Campaign; Akershus Universitetssykehus; Centre Hospitalier Universitaire de Québec; Université Laval; Cancer Council Tasmania; Francis Crick Institute; National Institutes of Health; David F. and Margaret T. Grohne Family Foundation; Helsingin ja Uudenmaan Sairaanhoitopiiri; Medisinske fakultet, Universitetet i Oslo; Ligue Contre le Cancer; Deutsches Krebsforschungszentrum; Universitetet i Bergen; Génome Québec; Associazione Italiana per la Ricerca sul Cancro","keywords":"Surgical oncology; Ductal carcinoma; Breast cancer; Medicine; Genetic predisposition; Oncology; Internal medicine; Cancer; Disease","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002675196,0.00008910941,0.00008632783,0.0001018958,0.00006209937,0.00001125621,0.0003816424,0.00008105388,0.0000921258],"category_scores_gemma":[0.00003124309,0.00005808888,0.00005010071,0.000398297,0.0001886976,0.000004542688,0.0002782942,0.00009081968,0.00001382357],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002811301,"about_ca_system_score_gemma":0.0006085025,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0006226196,"about_ca_topic_score_gemma":0.001503405,"domain_scores_codex":[0.9986464,0.0001585352,0.0001711047,0.0003334088,0.000361695,0.0003288777],"domain_scores_gemma":[0.9991024,0.00001697787,0.000033014,0.0004756721,0.000296049,0.00007587171],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"observational","study_design_scores_codex":[0.0002249828,0.00003911093,0.1225025,0.00001557345,0.00001334248,0.000001910182,0.00009054917,0.00008658466,0.8577654,0.00002516688,0.00219022,0.01704466],"study_design_scores_gemma":[0.0003925665,0.00004844893,0.7708789,0.00006210375,0.000003237877,0.0001115262,0.00004385546,0.00000424051,0.227631,0.00005597686,0.0006949207,0.00007327715],"study_design_candidate":"bench_or_experimental","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9936364,0.0003311972,0.00008235559,0.004688855,0.0001403337,0.0003553041,0.0002973153,0.000003151687,0.0004651354],"genre_scores_gemma":[0.9987668,0.00005022347,0.00007823567,0.00006252698,0.0003485649,0.0002226937,0.000003786092,0.0000205445,0.0004465628],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.6483764,"threshold_uncertainty_score":0.2368796,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01978692992831823,"score_gpt":0.3301965563032143,"score_spread":0.3104096263748961,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). 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