{"id":"W2287953281","doi":"10.1016/j.ahj.2016.01.019","title":"Impact of PCSK9 inhibition on coronary atheroma progression: Rationale and design of Global Assessment of Plaque Regression with a PCSK9 Antibody as Measured by Intravascular Ultrasound (GLAGOV)","year":2016,"lang":"en","type":"article","venue":"American Heart Journal","topic":"Lipoproteins and Cardiovascular Health","field":"Medicine","cited_by":58,"is_retracted":false,"has_abstract":false,"ca_institutions":"Libin Cardiovascular Institute of Alberta; Montreal Heart Institute","funders":"Amgen","keywords":"Evolocumab; Medicine; PCSK9; Intravascular ultrasound; Atheroma; Cardiology; Internal medicine; Placebo; Statin; Alirocumab; Coronary atherosclerosis; Rosuvastatin; Clinical trial; Coronary artery disease; Urology; Cholesterol; Lipoprotein; Pathology; LDL receptor","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.005265685,0.001693837,0.002742572,0.0007795094,0.0009684837,0.001153128,0.001253184,0.001266195,0.001796991],"category_scores_gemma":[0.002360628,0.0007511048,0.001094919,0.0007192471,0.002212719,0.0007689855,0.000951638,0.003424658,0.0004485633],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0007868051,"about_ca_system_score_gemma":0.002521169,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0007637172,"about_ca_topic_score_gemma":0.001408024,"domain_scores_codex":[0.9969753,0.001325781,0.0002243626,0.0006053616,0.000473211,0.0003959225],"domain_scores_gemma":[0.9985923,0.0002834028,0.0002297514,0.0003182059,0.0001730374,0.0004031959],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"theoretical_or_conceptual","study_design_scores_codex":[0.4374568,0.03233656,0.01202147,0.0009199397,0.0008453975,0.0002380612,0.0004817152,0.006536015,0.3629942,0.00402266,0.001903987,0.1402431],"study_design_scores_gemma":[0.07767557,0.4951886,0.03076575,0.0001111504,0.003154162,0.0003551105,0.0002306189,0.01357189,0.36124,0.002785088,0.01471957,0.0002026087],"study_design_candidate":"theoretical_or_conceptual","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"protocol","genre_scores_codex":[0.9437895,0.002643449,0.03552935,0.0007796115,0.0006942196,0.01098019,0.001193779,0.0003579603,0.004031915],"genre_scores_gemma":[0.9396166,0.001203803,0.04042097,0.0005569329,0.0002625041,0.01503291,0.0004201157,0.0001432728,0.0023427],"genre_candidate":"protocol","genre_consensus":null,"teacher_disagreement_score":0.005265685,"threshold_uncertainty_score":0.02784795,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01653942157832703,"score_gpt":0.3417451698708911,"score_spread":0.325205748292564,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}