{"id":"W2287953281","doi":"10.1016/j.ahj.2016.01.019","title":"Impact of PCSK9 inhibition on coronary atheroma progression: Rationale and design of Global Assessment of Plaque Regression with a PCSK9 Antibody as Measured by Intravascular Ultrasound (GLAGOV)","year":2016,"lang":"en","type":"article","venue":"American Heart Journal","topic":"Lipoproteins and Cardiovascular Health","field":"Medicine","cited_by":58,"is_retracted":false,"has_abstract":false,"ca_institutions":"Libin Cardiovascular Institute of Alberta; Montreal Heart Institute","funders":"Amgen","keywords":"Evolocumab; Medicine; PCSK9; Intravascular ultrasound; Atheroma; Cardiology; Internal medicine; Placebo; Statin; Alirocumab; Coronary atherosclerosis; Rosuvastatin; Clinical trial; Coronary artery disease; Urology; Cholesterol; Lipoprotein; Pathology; LDL receptor","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0009795874,0.0001960696,0.0007387167,0.00007208181,0.00008157986,0.000009703444,0.00005029075,0.00006643462,0.00006817029],"category_scores_gemma":[0.0001037562,0.0001020111,0.0002481023,0.0002493659,0.0004175154,0.0001219268,0.00001549868,0.0001814848,6.380143e-7],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000229068,"about_ca_system_score_gemma":0.0009879273,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002200468,"about_ca_topic_score_gemma":0.000002555883,"domain_scores_codex":[0.9974593,0.0004558162,0.0004831774,0.000229031,0.001142067,0.000230599],"domain_scores_gemma":[0.998432,0.0001257267,0.0005323181,0.00029739,0.0003516942,0.0002609035],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"observational","study_design_scores_codex":[0.00286226,0.0007554492,0.3982732,0.00009924154,0.0007944424,0.00006496823,0.0001136494,0.00005023196,0.5634941,0.00003520695,0.0005742023,0.03288306],"study_design_scores_gemma":[0.005281465,0.02269143,0.9248248,0.003410904,0.0002393925,0.006651785,0.0002619158,0.00005411497,0.03616665,0.00008320677,0.0001337483,0.0002005792],"study_design_candidate":"observational","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9871786,0.0006925441,0.01095603,0.0003528067,0.00002405272,0.0006973608,0.00004780063,0.000009446039,0.00004132488],"genre_scores_gemma":[0.9939361,0.0005445582,0.005328768,0.00005253532,0.00008491138,0.00001250011,0.00001416165,0.00001966401,0.000006848526],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.5273274,"threshold_uncertainty_score":0.415989,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01653942157832703,"score_gpt":0.3417451698708911,"score_spread":0.325205748292564,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}