{"id":"W2288405246","doi":"10.1096/fasebj.24.1_supplement.609.1","title":"Sphingosine‐1‐Phosphate acutely modulates the CFTR (Cystic Fibrosis Transmembrane Regulator) transporter in an AMPK‐dependent manner","year":2010,"lang":"en","type":"article","venue":"The FASEB Journal","topic":"Drug Transport and Resistance Mechanisms","field":"Medicine","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"Hospital for Sick Children; University of Toronto","funders":"","keywords":"Cystic fibrosis transmembrane conductance regulator; AMPK; Chemistry; Sphingosine-1-phosphate; Intracellular; Sphingosine kinase 1; Sphingosine; Sphingosine kinase; Phosphorylation; Cell biology; Protein kinase A; Endocrinology; Biochemistry; Receptor; Biology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001275758,0.0002890735,0.0003951598,0.0001357614,0.0001157176,0.0002778619,0.0001588992,0.0003389373,0.002746649],"category_scores_gemma":[0.0001173848,0.0001436992,0.0003270585,0.0001162905,0.0003077381,0.0002860792,0.0001730041,0.0007341561,0.0003593295],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002111186,"about_ca_system_score_gemma":0.0002402071,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0003926035,"about_ca_topic_score_gemma":0.0005649649,"domain_scores_codex":[0.9998398,0.00002652079,0.00001490592,0.00003122955,0.00003304588,0.00005452263],"domain_scores_gemma":[0.9999334,0.00001376965,0.00001741696,0.000006870228,0.000008621495,0.00002001557],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.001156321,0.00007452597,0.0001066876,0.00008353265,0.00000728902,0.00005051714,0.00001732102,0.00004285809,0.9973573,0.00006111497,0.0001152359,0.0009273337],"study_design_scores_gemma":[0.0001919224,0.00183828,0.00790223,0.00001926953,0.00004483592,0.0001763031,0.00009120614,0.00108385,0.9851218,0.0001108773,0.003408381,0.0000109743],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9950478,0.001716104,0.0009773183,0.0002625604,0.0001170721,0.00003914802,0.0004914101,0.00008406001,0.001264532],"genre_scores_gemma":[0.9935813,0.001454912,0.001135154,0.0001762622,0.0000528067,0.0001201717,0.0004274425,0.00001836003,0.0030336],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002746649,"threshold_uncertainty_score":0.009188414,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01016324078157301,"score_gpt":0.2352847572319622,"score_spread":0.2251215164503891,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}