{"id":"W2288598396","doi":"10.1371/journal.pone.0149996","title":"Biochemical Screening of Five Protein Kinases from Plasmodium falciparum against 14,000 Cell-Active Compounds","year":2016,"lang":"en","type":"article","venue":"PLoS ONE","topic":"Malaria Research and Control","field":"Medicine","cited_by":56,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Toronto; Structural Genomics Consortium","funders":"National Institute of Allergy and Infectious Diseases; National Institute of General Medical Sciences; University of Washington; Medicines for Malaria Venture; St. Jude Children's Research Hospital; National Cancer Institute; Yale University; Monash University; Cisco Systems; GlaxoSmithKline","keywords":"Kinome; Kinase; Plasmodium falciparum; Biology; Protein kinase A; Biochemistry; Drug discovery; Malaria; Immunology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001004093,0.0001657852,0.0004775972,0.0001006682,0.00004689247,0.00001198388,0.0001664652,0.0001228365,0.000401716],"category_scores_gemma":[0.0004255085,0.000116379,0.00009565124,0.0001122564,0.0001660381,0.00007969663,0.00009701098,0.0002218825,0.00006002096],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00005978003,"about_ca_system_score_gemma":0.0001063675,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002676225,"about_ca_topic_score_gemma":0.00000803559,"domain_scores_codex":[0.9983041,0.00007050434,0.0002641238,0.0003183882,0.0006512017,0.0003916296],"domain_scores_gemma":[0.9987788,0.0002465628,0.0001103601,0.0003542388,0.0002398703,0.0002701441],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.002879089,0.001550145,0.0009433617,0.000102983,0.0004260504,0.00003646011,0.00008909744,1.883652e-7,0.9921839,0.00004286792,0.0006550752,0.001090816],"study_design_scores_gemma":[0.005004707,0.0005111868,0.00383789,0.001093792,0.0001242373,5.807282e-7,0.0001097429,0.0003168811,0.9886351,0.00009396324,0.0001301454,0.0001417684],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9898098,0.0001785074,0.0003156937,0.003211182,0.00001140371,0.0008427847,0.0004363815,0.00005376374,0.00514052],"genre_scores_gemma":[0.9951268,0.00002886961,0.002277541,0.0001145666,0.0001949527,0.0001291614,0.0000861342,0.00002595628,0.002015991],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.005317064,"threshold_uncertainty_score":0.4745798,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0370921766394249,"score_gpt":0.2496515702344066,"score_spread":0.2125593935949817,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}