{"id":"W2288598396","doi":"10.1371/journal.pone.0149996","title":"Biochemical Screening of Five Protein Kinases from Plasmodium falciparum against 14,000 Cell-Active Compounds","year":2016,"lang":"en","type":"article","venue":"PLoS ONE","topic":"Malaria Research and Control","field":"Medicine","cited_by":56,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Toronto; Structural Genomics Consortium","funders":"National Institute of Allergy and Infectious Diseases; National Institute of General Medical Sciences; University of Washington; Medicines for Malaria Venture; St. Jude Children's Research Hospital; National Cancer Institute; Yale University; Monash University; Cisco Systems; GlaxoSmithKline","keywords":"Kinome; Kinase; Plasmodium falciparum; Biology; Protein kinase A; Biochemistry; Drug discovery; Malaria; Immunology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003370137,0.0008429801,0.0006019971,0.000812345,0.0003190846,0.0003405123,0.000354689,0.0003234621,0.00250006],"category_scores_gemma":[0.000335151,0.0003032685,0.0003584375,0.001119584,0.0002196738,0.000284252,0.0003742886,0.0004880457,0.0008770027],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003256826,"about_ca_system_score_gemma":0.000574038,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001176915,"about_ca_topic_score_gemma":0.002731049,"domain_scores_codex":[0.9997268,0.00004738136,0.00003138863,0.00004866664,0.0001075205,0.00003822308],"domain_scores_gemma":[0.9998418,0.00004104539,0.00001982272,0.00001077804,0.000048425,0.0000381276],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0006559846,0.0004489299,0.00225966,0.0005772243,0.00006671892,0.0002816606,0.00008625929,0.001358723,0.9784001,0.0001923612,0.0009671788,0.01470521],"study_design_scores_gemma":[0.000640574,0.01093849,0.03552727,0.0001186583,0.0004264537,0.00203541,0.0002151141,0.002714981,0.9049621,0.0003417995,0.04200814,0.00007096594],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9647522,0.01386632,0.004322319,0.0004563126,0.00005954189,0.0007964876,0.007624389,0.0002476123,0.007874819],"genre_scores_gemma":[0.9128765,0.02350089,0.0144373,0.0004262218,0.00007361138,0.0006848744,0.03702627,0.00006999012,0.01090433],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.00250006,"threshold_uncertainty_score":0.008363545,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0370921766394249,"score_gpt":0.2496515702344066,"score_spread":0.2125593935949817,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}