{"id":"W2288656535","doi":"10.1111/jnc.13541","title":"Prion protein in exosomes: partnering Aβ peptides and driving fibrilization","year":2016,"lang":"en","type":"letter","venue":"Journal of Neurochemistry","topic":"Prion Diseases and Protein Misfolding","field":"Biochemistry, Genetics and Molecular Biology","cited_by":2,"is_retracted":false,"has_abstract":true,"ca_institutions":"Western University","funders":"Canadian Institutes of Health Research; Fundação de Amparo à Pesquisa do Estado de São Paulo; Fondation Brain Canada","keywords":"Neurotoxicity; Microvesicles; Internalization; Fibril; Amyloid (mycology); Chemistry; Amyloid beta; Cell biology; Prion protein; Biochemistry; Biology; Peptide; Disease; Medicine; Toxicity; microRNA; Pathology; Cell","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0011421,0.0008460637,0.0006404064,0.0003237333,0.001051387,0.00222092,0.001085691,0.01791981,0.003110175],"category_scores_gemma":[0.006206207,0.000382722,0.0007460208,0.0001554326,0.001527749,0.002060256,0.0008176679,0.01300026,0.003596105],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.001290542,"about_ca_system_score_gemma":0.000461971,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0005086054,"about_ca_topic_score_gemma":0.000763401,"domain_scores_codex":[0.9990716,0.0001632218,0.0001054047,0.0001319328,0.0004354153,0.00009240993],"domain_scores_gemma":[0.9982577,0.0008749897,0.0001819304,0.00007265076,0.0003794469,0.0002332406],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"not_applicable","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001666769,0.00006093548,0.000293779,0.000191268,0.00002696196,0.006209628,0.0001026174,0.00009203651,0.003237642,0.00327055,0.9679542,0.01839378],"study_design_scores_gemma":[0.0001991796,0.0001778626,0.0008076974,0.0001499683,0.00003287324,0.007247179,0.0001656598,0.000508188,0.003385183,0.005875721,0.981412,0.00003850454],"study_design_candidate":"bench_or_experimental","study_design_consensus":null,"genre_codex":"commentary","genre_gemma":"empirical","genre_scores_codex":[0.002158693,0.01284585,0.0007090388,0.7611474,0.2173755,0.00003978836,0.00008253528,0.0001406599,0.005500629],"genre_scores_gemma":[0.01837763,0.01494693,0.0008729836,0.4824673,0.4591709,0.00006112029,0.00006649956,0.00005324178,0.02398347],"genre_candidate":"empirical","genre_consensus":null,"teacher_disagreement_score":0.01791981,"threshold_uncertainty_score":0.01040453,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.008830000043999617,"score_gpt":0.2382396155252114,"score_spread":0.2294096154812118,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}