{"id":"W2288746166","doi":"10.1096/fasebj.22.1_supplement.1050.5","title":"A requirement of growth factor receptor PTK and metalloproteinase activation in triggering endothelin‐1 (ET‐1)‐induced ERK1/2 and PKB phosphorylation In VSMC.","year":2008,"lang":"en","type":"article","venue":"The FASEB Journal","topic":"Cancer, Hypoxia, and Metabolism","field":"Biochemistry, Genetics and Molecular Biology","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"Université de Montréal","funders":"Canadian Institutes of Health Research","keywords":"Transactivation; Phosphorylation; Protein kinase B; Chemistry; Platelet-derived growth factor receptor; Tyrosine phosphorylation; Proto-oncogene tyrosine-protein kinase Src; Signal transduction; Cell biology; Epidermal growth factor; Endocrinology; Cancer research; Growth factor; Internal medicine; Receptor; Biology; Biochemistry; Medicine; Transcription factor","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001626896,0.0002889231,0.0002366801,0.0001978404,0.0001727051,0.0002854918,0.0001262054,0.0002851991,0.001206768],"category_scores_gemma":[0.0001250895,0.0001588762,0.0003333611,0.0001321584,0.0002080701,0.0002899869,0.0001663924,0.0005224257,0.0003250228],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003155948,"about_ca_system_score_gemma":0.0003241999,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0006209743,"about_ca_topic_score_gemma":0.0008890278,"domain_scores_codex":[0.9998369,0.00002547227,0.00002073383,0.00002732286,0.00004495679,0.00004459975],"domain_scores_gemma":[0.9998947,0.00001780441,0.00002833548,0.00001502855,0.00001018284,0.00003395843],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001759348,0.00005065115,0.0001830596,0.00004253101,0.000003585627,0.00008325985,0.0000108269,0.00002182007,0.9988877,0.00006933372,0.00001757832,0.0004537716],"study_design_scores_gemma":[0.00009814731,0.0007291303,0.04107781,0.00001225709,0.00003363665,0.001358325,0.00004972531,0.001370363,0.9531736,0.0001127728,0.001974643,0.000009583008],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9944367,0.002527813,0.00130853,0.0001186465,0.00004249542,0.00003480111,0.0003807207,0.00003415778,0.001116056],"genre_scores_gemma":[0.9943006,0.001049619,0.002080443,0.00004421971,0.0000181682,0.00008980777,0.0008234417,0.000006930405,0.001586782],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001206768,"threshold_uncertainty_score":0.004037023,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02541650141766992,"score_gpt":0.2536783352209483,"score_spread":0.2282618338032784,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}