{"id":"W2288810364","doi":"10.1039/c5mb00706b","title":"An updated evolutionary study of <i>Flaviviridae</i> NS3 helicase and NS5 RNA-dependent RNA polymerase reveals novel invariable motifs as potential pharmacological targets","year":2016,"lang":"en","type":"article","venue":"Molecular BioSystems","topic":"Mosquito-borne diseases and control","field":"Medicine","cited_by":51,"is_retracted":false,"has_abstract":true,"ca_institutions":"International Game Technology (Canada)","funders":"","keywords":"Flaviviridae; Helicase; Biology; RNA polymerase; NS3; Virology; Genetics; RNA; Polymerase; Computational biology; Evolutionary biology; Hepatitis C virus; Virus; Gene","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002379216,0.0003500531,0.0003058398,0.0008756142,0.000278691,0.0005915649,0.0002348246,0.0002737081,0.0008896281],"category_scores_gemma":[0.0002650316,0.0001238933,0.0002864605,0.0008912482,0.0002013318,0.001052533,0.0002715435,0.0005633523,0.0004016809],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003097842,"about_ca_system_score_gemma":0.0004306049,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0008579199,"about_ca_topic_score_gemma":0.0009227694,"domain_scores_codex":[0.9999,0.00001609691,0.00001085805,0.00002551672,0.00003082433,0.00001664549],"domain_scores_gemma":[0.9998234,0.00002033617,0.00006093713,0.00001195734,0.00005502204,0.00002837859],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"simulation_or_modeling","study_design_scores_codex":[0.0005717654,0.00009136017,0.04439724,0.001684528,0.0001841783,0.0008431504,0.0006638475,0.00376191,0.4478849,0.006260395,0.003287391,0.4903692],"study_design_scores_gemma":[0.00004546954,0.001635494,0.3374652,0.0007260286,0.0008631096,0.009600394,0.001950595,0.04413321,0.1458692,0.01458827,0.4429488,0.0001742185],"study_design_candidate":"simulation_or_modeling","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.7470659,0.1545893,0.07186867,0.002922417,0.0003798348,0.0001011051,0.002466324,0.0005201134,0.02008644],"genre_scores_gemma":[0.8583461,0.08249775,0.04782155,0.0005787725,0.0002901629,0.00004583248,0.005902871,0.00007226371,0.004444674],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0008896281,"threshold_uncertainty_score":0.00297612,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.008073544216707702,"score_gpt":0.2674597529062567,"score_spread":0.259386208689549,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}