{"id":"W2288810364","doi":"10.1039/c5mb00706b","title":"An updated evolutionary study of <i>Flaviviridae</i> NS3 helicase and NS5 RNA-dependent RNA polymerase reveals novel invariable motifs as potential pharmacological targets","year":2016,"lang":"en","type":"article","venue":"Molecular BioSystems","topic":"Mosquito-borne diseases and control","field":"Medicine","cited_by":51,"is_retracted":false,"has_abstract":true,"ca_institutions":"International Game Technology (Canada)","funders":"","keywords":"Flaviviridae; Helicase; Biology; RNA polymerase; NS3; Virology; Genetics; RNA; Polymerase; Computational biology; Evolutionary biology; Hepatitis C virus; Virus; Gene","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003809812,0.0003411194,0.0006507837,0.0001466036,0.0001219711,0.00003664337,0.0002269794,0.0001669006,0.0003814874],"category_scores_gemma":[0.00006431987,0.0002384596,0.0001511148,0.0002080651,0.00008404363,0.0001308508,0.0001367398,0.0001427733,0.00003037155],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00007696824,"about_ca_system_score_gemma":0.00013439,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0006418955,"about_ca_topic_score_gemma":0.000006184795,"domain_scores_codex":[0.9971741,0.0003171604,0.0006819164,0.0007468518,0.0006060858,0.0004738186],"domain_scores_gemma":[0.9982601,0.00002948754,0.0002642837,0.0006145707,0.0002401515,0.0005914005],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.001768161,0.003306259,0.001601947,0.00006401008,0.0004671091,0.001370191,0.00004564605,0.00001674976,0.9897752,0.0001479204,0.0008343636,0.000602473],"study_design_scores_gemma":[0.06394745,0.01690207,0.01363022,0.0006296047,0.004401512,0.001603739,0.001808837,0.005775123,0.8883675,0.0001462475,0.00111807,0.001669681],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9921954,0.00272493,0.001902203,0.0005484687,0.0002800049,0.001819315,0.0002672473,0.000090212,0.0001722005],"genre_scores_gemma":[0.9984614,0.00003841126,0.00007522281,0.0006964653,0.0002232527,0.0001074509,0.00008074962,0.00004735349,0.0002697413],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.1014077,"threshold_uncertainty_score":0.9724099,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.008073544216707702,"score_gpt":0.2674597529062567,"score_spread":0.259386208689549,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}