{"id":"W2288853532","doi":"10.1089/ten.tea.2015.0458","title":"Preparation of Scaffold-Free Tissue-Engineered Constructs Derived from Human Synovial Mesenchymal Stem Cells Under Low Oxygen Tension Enhances Their Chondrogenic Differentiation Capacity","year":2016,"lang":"en","type":"article","venue":"Tissue Engineering Part A","topic":"Osteoarthritis Treatment and Mechanisms","field":"Medicine","cited_by":33,"is_retracted":false,"has_abstract":true,"ca_institutions":"Alberta Bone and Joint Health Institute; University of Calgary","funders":"National Institutes of Health; Japan Society for the Promotion of Science; Alberta Innovates - Health Solutions","keywords":"Chondrogenesis; Mesenchymal stem cell; Oxygen tension; Hyaline cartilage; Tissue engineering; Cartilage; Cell biology; Scaffold; Stem cell; Biomedical engineering; Chemistry; Cellular differentiation; Regeneration (biology); Anatomy; Pathology; Biology; Medicine; Osteoarthritis; Articular cartilage; Biochemistry; Oxygen","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00008215129,0.0003185377,0.0005139008,0.0001281189,0.00006493468,0.00001895548,0.0001261667,0.0001876732,0.0001888068],"category_scores_gemma":[0.00002433278,0.0002421786,0.00009211702,0.0001222374,0.00005028163,0.0001738446,0.00005282503,0.00008451692,0.00004625319],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00009584986,"about_ca_system_score_gemma":0.00003743226,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00002622253,"about_ca_topic_score_gemma":0.00003563384,"domain_scores_codex":[0.9985217,0.00003556679,0.0004329221,0.0003842703,0.0003031188,0.000322397],"domain_scores_gemma":[0.9989939,0.00008805916,0.0001485112,0.0005076584,0.0001040713,0.0001578091],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00006380417,0.00008059845,0.00006580596,0.00006759378,0.0001118265,0.000009179465,0.0003040195,0.00007388792,0.9962854,0.000252594,0.0000615534,0.002623674],"study_design_scores_gemma":[0.002926066,0.0007420313,0.001413263,0.0005825583,0.0001485792,0.00001737834,0.00003908325,0.0001729382,0.9933582,0.0001211378,0.0002283132,0.0002504564],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9905087,0.000419206,0.007175552,0.00005958881,0.0007705187,0.0006836444,0.0001314881,0.0002097892,0.00004154596],"genre_scores_gemma":[0.9974928,0.00003457043,0.001408204,0.000006610485,0.0002996689,0.0000491178,0.0001026828,0.00004836319,0.0005579224],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.006984193,"threshold_uncertainty_score":0.9875757,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0153833952449467,"score_gpt":0.2337447373199273,"score_spread":0.2183613420749806,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}