{"id":"W2288862687","doi":"10.1021/acs.biomac.6b00172","title":"Membrane Translocation and Organelle-Selective Delivery Steered by Polymeric Zwitterionic Nanospheres","year":2016,"lang":"en","type":"article","venue":"Biomacromolecules","topic":"RNA Interference and Gene Delivery","field":"Biochemistry, Genetics and Molecular Biology","cited_by":38,"is_retracted":false,"has_abstract":true,"ca_institutions":"Université de Montréal","funders":"Japan Society for the Promotion of Science; Ministry of Education, Culture, Sports, Science and Technology","keywords":"Endocytosis; Endosome; Nanocarriers; Biophysics; Chemistry; Drug delivery; HeLa; Cytoplasm; Cell membrane; Drug carrier; Cell biology; Cell; Biochemistry; Biology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0000527326,0.0001978774,0.0001433101,0.00003394735,0.00008567551,0.00003091772,0.0001588413,0.0001413293,0.0001223608],"category_scores_gemma":[0.00001993112,0.0001482208,0.000060671,0.00009443657,0.0001447107,0.000009688397,0.00005234894,0.00002940571,0.00006030091],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00001411979,"about_ca_system_score_gemma":0.00004890258,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00007307948,"about_ca_topic_score_gemma":0.00003366356,"domain_scores_codex":[0.9989656,0.00006143744,0.0001853407,0.0004308257,0.0001038255,0.0002529566],"domain_scores_gemma":[0.9995362,0.00001336869,0.00006512487,0.0002256891,0.00007405497,0.00008555246],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001238703,0.00003609844,0.0002153108,0.00000854482,0.000075637,0.000003863687,0.00003573772,1.607627e-7,0.9611961,0.000008425495,0.002928658,0.03536758],"study_design_scores_gemma":[0.0006529436,0.0003702327,0.000748274,0.00002963003,0.00001796451,0.00004125448,0.00005051263,0.000003754252,0.9924688,0.00001661663,0.005352843,0.0002471305],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9922068,0.005080979,0.001781801,0.0003184825,0.00006664554,0.0001342003,0.00006495434,0.00002414737,0.0003220034],"genre_scores_gemma":[0.996113,0.001828452,0.0001045108,0.000208134,0.00006244276,0.00001994197,0.00006655827,0.00002795702,0.001568987],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.03512045,"threshold_uncertainty_score":0.604427,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.004334388252909715,"score_gpt":0.1985328946845616,"score_spread":0.1941985064316519,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}