{"id":"W2288862687","doi":"10.1021/acs.biomac.6b00172","title":"Membrane Translocation and Organelle-Selective Delivery Steered by Polymeric Zwitterionic Nanospheres","year":2016,"lang":"en","type":"article","venue":"Biomacromolecules","topic":"RNA Interference and Gene Delivery","field":"Biochemistry, Genetics and Molecular Biology","cited_by":38,"is_retracted":false,"has_abstract":true,"ca_institutions":"Université de Montréal","funders":"Japan Society for the Promotion of Science; Ministry of Education, Culture, Sports, Science and Technology","keywords":"Endocytosis; Endosome; Nanocarriers; Biophysics; Chemistry; Drug delivery; HeLa; Cytoplasm; Cell membrane; Drug carrier; Cell biology; Cell; Biochemistry; Biology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001036251,0.000292752,0.0001259482,0.0001311285,0.0001100281,0.0002015742,0.0001639678,0.0001854702,0.0003056122],"category_scores_gemma":[0.0001366224,0.0001108788,0.0001450743,0.00007535276,0.0001995647,0.0002704062,0.0001815984,0.0001934921,0.0002141712],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002836207,"about_ca_system_score_gemma":0.0002074285,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0005150815,"about_ca_topic_score_gemma":0.0005667401,"domain_scores_codex":[0.9999255,0.00001084262,0.000004766325,0.00002118121,0.00002346743,0.00001419389],"domain_scores_gemma":[0.9999433,0.00001099369,0.00002248058,0.00000631896,0.000009177861,0.00000774835],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.000009021209,0.000002684298,0.00001989224,0.000008618456,9.008094e-7,0.00001436991,0.000007933427,0.00007607585,0.9992996,0.00006848136,0.000006928394,0.0004853451],"study_design_scores_gemma":[0.000003645184,0.00004157355,0.0002188213,9.139898e-7,0.000001880807,0.00003837459,0.000005822788,0.0008991412,0.9982055,0.00002607998,0.0005558918,0.00000224564],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9928798,0.0005484595,0.005510428,0.00004988196,0.000008661202,0.00002494284,0.00004164905,0.00007201706,0.0008642526],"genre_scores_gemma":[0.9922759,0.0006451986,0.005238117,0.00002632224,0.000006467439,0.00003871884,0.00005911467,0.00003062334,0.001679579],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0005150815,"threshold_uncertainty_score":0.002057791,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.004334388252909715,"score_gpt":0.1985328946845616,"score_spread":0.1941985064316519,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}