{"id":"W2289147497","doi":"10.1016/j.neurobiolaging.2016.02.024","title":"Assessment of the genetic variance of late-onset Alzheimer's disease","year":2016,"lang":"en","type":"article","venue":"Neurobiology of Aging","topic":"Alzheimer's disease research and treatments","field":"Medicine","cited_by":255,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"Janssen Research and Development; National Center for Research Resources; National Institute of Neurological Disorders and Stroke; National Institute of Mental Health; National Institute on Aging; Genentech; Alzheimer's Drug Discovery Foundation; National Institutes of Health; H. Lundbeck A/S; GE Healthcare; Universitat de Barcelona; Fujirebio Europe; Medical Research Council; Servier; Canadian Institutes of Health Research; Stichting MS Research; Newcastle University; Higher Education Funding Council for England; National Association for Colitis and Crohn's Disease; North Bristol NHS Trust; Banner Alzheimer’s Foundation; Northern California Institute for Research and Education; IXICO; Takeda Pharmaceutical Company; Biogen; Pfizer; BioClinica; Alzheimer's Disease Neuroimaging Initiative; Biomedical Laboratory Research and Development, VA Office of Research and Development; U.S. Department of Defense; BRACE; F. Hoffmann-La Roche; U.S. Department of Veterans Affairs; University of Pennsylvania; Wellcome Trust; Eisai; University of Southern California; Hersenstichting; Eli Lilly and Company; Brigham Young University; AbbVie; University of California, San Diego; Office of Research and Development; Merck; GlaxoSmithKline; National Center for Advancing Translational Sciences; Novartis Pharmaceuticals Corporation; Wellcome; Alzheimer's Association; National Cancer Institute; Lundbeckfonden; Alzheimer's Research Trust; Bristol-Myers Squibb; Howard Hughes Medical Institute; National Institute of Biomedical Imaging and Bioengineering; National Human Genome Research Institute; Johnson and Johnson; Meso Scale Diagnostics","keywords":"Single-nucleotide polymorphism; Biology; TREM2; Genetic architecture; Genetic variation; Genetics; Genome-wide association study; Phenotype; Genetic association; Explained variation; Genotype; Gene; Receptor; Statistics","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001859724,0.0005477857,0.0003941084,0.0009792444,0.0003319239,0.0004050742,0.0003649681,0.0003624106,0.0006768278],"category_scores_gemma":[0.004581473,0.0001348065,0.0005850078,0.0009483791,0.0003407441,0.0001829,0.0004337069,0.0003710252,0.00009204671],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002599662,"about_ca_system_score_gemma":0.0002516787,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.002667882,"about_ca_topic_score_gemma":0.002955735,"domain_scores_codex":[0.9980584,0.0009918778,0.0001095358,0.0004745824,0.000271949,0.00009354007],"domain_scores_gemma":[0.998395,0.0009201338,0.0002830875,0.0002011812,0.00009962092,0.0001008506],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.0007573311,0.000123293,0.9572884,0.00003467505,0.001411705,0.0004529212,0.0002886741,0.003862724,0.015001,0.001058106,0.0002128135,0.01950834],"study_design_scores_gemma":[0.00002042867,0.0002351195,0.9857118,0.000006385824,0.0002611531,0.0004959845,0.00008402581,0.01025178,0.001330579,0.001192451,0.000393537,0.00001679978],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9921405,0.0002818751,0.006975548,0.00004471534,0.000009404685,0.00001271731,0.0002423738,0.00002567291,0.0002671941],"genre_scores_gemma":[0.9975404,0.0000574476,0.002079486,0.00001424504,0.000005921832,0.00001081993,0.0001704813,0.000008116238,0.0001130563],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002667882,"threshold_uncertainty_score":0.009835303,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02489107028902555,"score_gpt":0.3192397886491865,"score_spread":0.294348718360161,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}