{"id":"W2289412129","doi":"10.1111/jvh.12525","title":"<i><scp>HLA</scp>‐C</i> and <i><scp>KIR</scp></i> combined genotype as new response marker for <scp>HB</scp>eAg‐positive chronic hepatitis B patients treated with interferon‐based combination therapy","year":2016,"lang":"en","type":"article","venue":"Journal of Viral Hepatitis","topic":"Immune Cell Function and Interaction","field":"Immunology and Microbiology","cited_by":11,"is_retracted":false,"has_abstract":true,"ca_institutions":"University Health Network","funders":"Cilag; F. Hoffmann-La Roche; Alnylam Pharmaceuticals; Gilead Sciences; Bristol-Myers Squibb","keywords":"Genotype; Medicine; Immunology; Human leukocyte antigen; SNP; Internal medicine; Gastroenterology; Single-nucleotide polymorphism; Antigen; Biology; Gene; Genetics","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0004900297,0.0003243963,0.000505149,0.000465684,0.0001965974,0.000401156,0.0001432402,0.0003639964,0.001111258],"category_scores_gemma":[0.0009924013,0.0001006614,0.0004270241,0.0003950583,0.0001956059,0.000156301,0.0001573116,0.0003837029,0.0002154965],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001439072,"about_ca_system_score_gemma":0.00009738127,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0004682968,"about_ca_topic_score_gemma":0.0005963868,"domain_scores_codex":[0.9996526,0.0001526732,0.00003742902,0.00006404013,0.00005415355,0.00003908174],"domain_scores_gemma":[0.9990919,0.0002752017,0.0003541142,0.00005429823,0.00007228956,0.0001522105],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.00421982,0.0001170216,0.9704019,0.00002736689,0.0002496621,0.0002577853,0.0000896934,0.0002988364,0.01529871,0.00002148007,0.0001456871,0.008872051],"study_design_scores_gemma":[0.00007160378,0.0006510186,0.99527,0.000009236004,0.0001645922,0.0007452452,0.00007614888,0.001363906,0.00137206,0.00005410739,0.0002137186,0.000008427115],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9995141,0.0001444206,0.0001076223,0.00001663389,0.000004341288,0.000004409275,0.00003745876,0.000003666366,0.0001674391],"genre_scores_gemma":[0.9997556,0.00002125435,0.00008461041,0.0000149998,0.000006638782,0.000003218002,0.00004914456,0.000001596488,0.00006297037],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001111258,"threshold_uncertainty_score":0.003717542,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.006820369655337944,"score_gpt":0.2189690249082984,"score_spread":0.2121486552529604,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}