{"id":"W2289412129","doi":"10.1111/jvh.12525","title":"<i><scp>HLA</scp>‐C</i> and <i><scp>KIR</scp></i> combined genotype as new response marker for <scp>HB</scp>eAg‐positive chronic hepatitis B patients treated with interferon‐based combination therapy","year":2016,"lang":"en","type":"article","venue":"Journal of Viral Hepatitis","topic":"Immune Cell Function and Interaction","field":"Immunology and Microbiology","cited_by":11,"is_retracted":false,"has_abstract":true,"ca_institutions":"University Health Network","funders":"Cilag; F. Hoffmann-La Roche; Alnylam Pharmaceuticals; Gilead Sciences; Bristol-Myers Squibb","keywords":"Genotype; Medicine; Immunology; Human leukocyte antigen; SNP; Internal medicine; Gastroenterology; Single-nucleotide polymorphism; Antigen; Biology; Gene; Genetics","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.0006081585,0.0005433866,0.0007638313,0.0004804936,0.0004069614,0.0001101325,0.000306086,0.0004595424,0.000168171],"category_scores_gemma":[0.001302367,0.0003924174,0.0003096089,0.000271583,0.0002913694,0.0008807772,0.00006331993,0.0005364848,0.000176615],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000542142,"about_ca_system_score_gemma":0.0004786457,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000812385,"about_ca_topic_score_gemma":0.0001739631,"domain_scores_codex":[0.9967698,0.000857295,0.0010153,0.0004734962,0.000219972,0.0006641088],"domain_scores_gemma":[0.9946721,0.00255635,0.001250824,0.0003282336,0.001013131,0.0001794227],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.009490291,0.001678397,0.2321793,0.00006845652,0.00173133,0.00005684918,0.001388728,0.000009548195,0.4200816,0.0002099518,0.3061552,0.02695024],"study_design_scores_gemma":[0.03077688,0.04303266,0.2939563,0.0007551813,0.0002740502,0.0002167257,0.0001399167,0.00006940983,0.3762527,0.000211805,0.2541421,0.0001722691],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.99108,0.001825305,0.002513755,0.0003922788,0.002317754,0.0009034898,0.00008829711,0.00007277339,0.0008063276],"genre_scores_gemma":[0.9669467,0.002812874,0.0001568005,0.001427397,0.0001376177,0.00004885213,0.0002499368,0.00009679681,0.02812308],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.06177695,"threshold_uncertainty_score":0.9998528,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.006820369655337944,"score_gpt":0.2189690249082984,"score_spread":0.2121486552529604,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}