{"id":"W2289592036","doi":"10.1038/ncomms10822","title":"FAT1 mutations cause a glomerulotubular nephropathy","year":2016,"lang":"en","type":"article","venue":"Nature Communications","topic":"Renal Diseases and Glomerulopathies","field":"Medicine","cited_by":132,"is_retracted":false,"has_abstract":true,"ca_institutions":"Hospital for Sick Children; Lunenfeld-Tanenbaum Research Institute; University of Toronto; SickKids Foundation; Mount Sinai Hospital","funders":"National Institute of Dental and Craniofacial Research; National Institute of Diabetes and Digestive and Kidney Diseases; National Heart, Lung, and Blood Institute; King's College London; National Research Foundation of Korea; Deutsche Forschungsgemeinschaft; National Cancer Institute; National Research Foundation; National Institutes of Health; Kidney Research UK; ASN Foundation for Kidney Research; National Human Genome Research Institute; Wellcome Trust; National Institute for Health and Care Research; Medical Research Council; Nephcure Foundation; Howard Hughes Medical Institute","keywords":"Podocyte; RAC1; Pathogenesis; Zebrafish; Cancer research; Biology; Gene knockdown; Tubulopathy; Cell biology; Nephropathy; Kidney disease; Kidney; Internal medicine; Endocrinology; Medicine; Immunology; Diabetes mellitus; Genetics; Signal transduction; Proteinuria; Apoptosis; Gene","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001035343,0.0001382372,0.0001902483,0.0001459066,0.0002611215,0.00002224922,0.0003805419,0.0001902989,0.0001103924],"category_scores_gemma":[0.0004856159,0.00008870313,0.0001546508,0.0004000276,0.0002663007,0.0001358208,0.0001790525,0.0004072841,0.0002960346],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00007285172,"about_ca_system_score_gemma":0.0001311324,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00001416271,"about_ca_topic_score_gemma":0.00006574498,"domain_scores_codex":[0.9990566,0.00008340586,0.000236033,0.0001906991,0.0002290688,0.0002041504],"domain_scores_gemma":[0.9972033,0.0002413488,0.0000756302,0.00200499,0.0002764852,0.0001982484],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"theoretical_or_conceptual","study_design_gemma":"not_applicable","study_design_scores_codex":[0.0005540932,0.00374743,0.256596,0.00032723,0.001436013,0.0002609496,0.001810422,0.000005022037,0.1248071,0.3025138,0.1546931,0.1532489],"study_design_scores_gemma":[0.001974039,0.0001906292,0.3769338,0.0004077528,0.0005230869,0.0001688066,0.0002140592,0.00007189441,0.001455319,0.002477153,0.6152265,0.0003568878],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.5237933,0.151136,0.001708984,0.2571602,0.0008366922,0.002454395,0.0009008576,0.001344252,0.06066532],"genre_scores_gemma":[0.9895279,0.004364196,0.003173098,0.001459531,0.00008588292,0.00008571546,0.0001160166,0.00002524399,0.00116237],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.4657347,"threshold_uncertainty_score":0.3805024,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02074094070124503,"score_gpt":0.3193333703148326,"score_spread":0.2985924296135876,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}