{"id":"W2289692646","doi":"10.1161/atvb.34.suppl_1.659","title":"Abstract 659: PKR-Like Endoplasmic Reticulum Kinase and Glycogen Synthase Kinase-3α/ß Signaling Regulates Endoplasmic Reticulum Stress-Induced Foam Cell Formation","year":2014,"lang":"en","type":"article","venue":"Arteriosclerosis Thrombosis and Vascular Biology","topic":"Endoplasmic Reticulum Stress and Disease","field":"Biochemistry, Genetics and Molecular Biology","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"McMaster University","funders":"","keywords":"Unfolded protein response; Endoplasmic reticulum; ATF6; GSK-3; Thapsigargin; Cell biology; Protein kinase R; Kinase; Chemistry; GSK3B; Foam cell; Signal transduction; Protein kinase A; Biology; Biochemistry; Macrophage; Mitogen-activated protein kinase kinase","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.000116745,0.000488834,0.0002437141,0.0002324742,0.0001919286,0.0002736217,0.0001698646,0.0002882965,0.004004821],"category_scores_gemma":[0.00007803308,0.0001375643,0.0002496397,0.000183979,0.0002012115,0.0002460104,0.0001675295,0.0005587754,0.001784783],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002296382,"about_ca_system_score_gemma":0.0002469812,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0003278095,"about_ca_topic_score_gemma":0.0002725906,"domain_scores_codex":[0.9999347,0.000009569339,0.000006603238,0.00001475075,0.00001573198,0.00001868782],"domain_scores_gemma":[0.999943,0.000004220211,0.00002157899,0.000003614305,0.000008790744,0.0000187078],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0007350533,0.00004664114,0.0002532916,0.0001455539,0.000009420587,0.0001870796,0.00001442708,0.00005771981,0.9942115,0.000177757,0.0005591557,0.003602433],"study_design_scores_gemma":[0.0004203241,0.0009314104,0.02808591,0.00008238966,0.00007911979,0.001296654,0.00008373293,0.001459725,0.9523124,0.0006917048,0.01454036,0.00001643907],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.960253,0.01651495,0.005573475,0.001810603,0.0004596295,0.0001386633,0.002527097,0.0005664257,0.01215625],"genre_scores_gemma":[0.9728659,0.006369397,0.003824914,0.0004549329,0.0001445244,0.0001265859,0.002128429,0.00005626027,0.01402909],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.004004821,"threshold_uncertainty_score":0.0133974,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01394260916336369,"score_gpt":0.2356689438883711,"score_spread":0.2217263347250074,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}