{"id":"W2289834069","doi":"10.1021/acsinfecdis.5b00033","title":"Zinc Chelation by a Small-Molecule Adjuvant Potentiates Meropenem Activity in Vivo against NDM-1-Producing <i>Klebsiella pneumoniae</i>","year":2015,"lang":"en","type":"article","venue":"ACS Infectious Diseases","topic":"Antibiotic Resistance in Bacteria","field":"Biochemistry, Genetics and Molecular Biology","cited_by":55,"is_retracted":false,"has_abstract":true,"ca_institutions":"McMaster University","funders":"Canadian Institutes of Health Research; Canada Research Chairs","keywords":"Klebsiella pneumoniae; Meropenem; In vivo; Microbiology; Adjuvant; Medicine; Pharmacology; Chemistry; Biology; Antibiotics; Immunology; Escherichia coli; Antibiotic resistance; Biochemistry; Biotechnology; Gene","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001323594,0.0002621298,0.0002254505,0.0001581604,0.00006079397,0.0001388305,0.0001856634,0.0001324069,0.0006456757],"category_scores_gemma":[0.0001057864,0.00008074842,0.0001475512,0.00007677739,0.0001315922,0.000114311,0.0001058655,0.000305716,0.000148635],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00009869532,"about_ca_system_score_gemma":0.0001881767,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0004315486,"about_ca_topic_score_gemma":0.001088308,"domain_scores_codex":[0.9999424,0.00001352957,0.000004963041,0.000008349257,0.00001154743,0.00001910873],"domain_scores_gemma":[0.9999588,0.000007584403,0.00001089867,0.000003394217,0.000004284808,0.00001511792],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0007321701,0.0002132331,0.0001392136,0.00006356856,0.000006340444,0.00004916669,0.00001884452,0.0001451675,0.9940455,0.0000348397,0.00008579362,0.004466043],"study_design_scores_gemma":[0.0001482741,0.007869406,0.001973328,0.00001133682,0.00002885427,0.000186528,0.00001818445,0.0007821223,0.9868844,0.00002143451,0.00207049,0.000005815838],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9966487,0.001563522,0.0007000595,0.00005950851,0.00002703982,0.00002823616,0.00006267096,0.00005292095,0.0008572255],"genre_scores_gemma":[0.9964993,0.001108757,0.001066898,0.00002862343,0.00001483191,0.00001094081,0.0001358335,0.000006431289,0.001128273],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0006456757,"threshold_uncertainty_score":0.002159953,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.009651229167555396,"score_gpt":0.2335380394098465,"score_spread":0.2238868102422911,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}