{"id":"W2289834069","doi":"10.1021/acsinfecdis.5b00033","title":"Zinc Chelation by a Small-Molecule Adjuvant Potentiates Meropenem Activity in Vivo against NDM-1-Producing <i>Klebsiella pneumoniae</i>","year":2015,"lang":"en","type":"article","venue":"ACS Infectious Diseases","topic":"Antibiotic Resistance in Bacteria","field":"Biochemistry, Genetics and Molecular Biology","cited_by":55,"is_retracted":false,"has_abstract":true,"ca_institutions":"McMaster University","funders":"Canadian Institutes of Health Research; Canada Research Chairs","keywords":"Klebsiella pneumoniae; Meropenem; In vivo; Microbiology; Adjuvant; Medicine; Pharmacology; Chemistry; Biology; Antibiotics; Immunology; Escherichia coli; Antibiotic resistance; Biochemistry; Biotechnology; Gene","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.000184327,0.0002809915,0.0002642325,0.00006365342,0.0001019564,0.0000902209,0.0002090533,0.0001667891,0.00001076837],"category_scores_gemma":[0.0003683226,0.0002870279,0.00009646373,0.0001943887,0.0001050251,0.00002448041,0.0001758272,0.0001214276,0.00002041319],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00009485081,"about_ca_system_score_gemma":0.0001683835,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000211068,"about_ca_topic_score_gemma":0.0004274121,"domain_scores_codex":[0.998359,0.0001561527,0.0002709699,0.0006379876,0.0001900477,0.0003858823],"domain_scores_gemma":[0.9989509,0.00002210435,0.0001772159,0.0005234133,0.0001281806,0.000198195],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00009372648,0.0002781474,0.2368292,0.00002886074,0.0000470827,0.00001359032,0.00003705404,0.0001842295,0.7586693,0.000005643068,0.003062444,0.0007507296],"study_design_scores_gemma":[0.001827552,0.0003788484,0.08646999,0.00009681828,0.00009531064,0.00001868638,0.0001242858,0.0001103689,0.9063342,0.0001339707,0.003618423,0.0007916027],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9954401,0.001221469,0.000342725,0.00008943526,0.000269107,0.0003243532,0.00008193945,0.00006177599,0.002169112],"genre_scores_gemma":[0.9985453,0.0003736811,0.00003773229,0.0002434219,0.0001681783,0.00002434212,0.0001689681,0.00005017995,0.0003881998],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.1503592,"threshold_uncertainty_score":0.9999582,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.009651229167555396,"score_gpt":0.2335380394098465,"score_spread":0.2238868102422911,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}