{"id":"W2289862791","doi":"10.1038/srep22450","title":"Small Molecule Inhibition of Ligand-Stimulated RAGE-DIAPH1 Signal Transduction","year":2016,"lang":"en","type":"article","venue":"Scientific Reports","topic":"Advanced Glycation End Products research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":110,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"National Institute of Diabetes and Digestive and Kidney Diseases; National Heart, Lung, and Blood Institute; School of Medicine, New York University; York University; Juvenile Diabetes Research Foundation International","keywords":"Rage (emotion); Signal transduction; Glycation; Cell biology; Receptor; Inflammation; Extracellular; Chemistry; HMGB1; Biology; Biochemistry; Neuroscience; Immunology","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001463969,0.0004524385,0.0004054282,0.0003607881,0.0001523132,0.0002134139,0.0002055152,0.0002175811,0.002112492],"category_scores_gemma":[0.0001439729,0.0001500277,0.0002556099,0.0002428165,0.0001472514,0.0001220997,0.0001739238,0.0004694864,0.0003194386],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002699801,"about_ca_system_score_gemma":0.0002240055,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0005143804,"about_ca_topic_score_gemma":0.001824785,"domain_scores_codex":[0.9999243,0.00001115234,0.000004868908,0.00001253886,0.00001768185,0.0000295199],"domain_scores_gemma":[0.9999439,0.00002190815,0.00000914457,0.00000336764,0.000006612146,0.00001512065],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0005506523,0.0005245284,0.0003717885,0.0002464779,0.00005868512,0.0001691724,0.00003551173,0.0007475292,0.9724739,0.0004492759,0.0005096176,0.02386299],"study_design_scores_gemma":[0.0006581413,0.007490382,0.004199083,0.00003695958,0.00009684799,0.0004739661,0.00003275849,0.002292755,0.9757112,0.000161023,0.0088253,0.00002158343],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9824569,0.008677273,0.002532501,0.0002410765,0.00008080281,0.0002461196,0.0006824874,0.0001501927,0.004932686],"genre_scores_gemma":[0.9837107,0.007764434,0.002807484,0.0001553783,0.00002674179,0.0001719674,0.0008461103,0.00001718953,0.004500067],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002112492,"threshold_uncertainty_score":0.007066965,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01923520304407255,"score_gpt":0.2703225228442904,"score_spread":0.2510873198002178,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}