{"id":"W2289862791","doi":"10.1038/srep22450","title":"Small Molecule Inhibition of Ligand-Stimulated RAGE-DIAPH1 Signal Transduction","year":2016,"lang":"en","type":"article","venue":"Scientific Reports","topic":"Advanced Glycation End Products research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":110,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"National Institute of Diabetes and Digestive and Kidney Diseases; National Heart, Lung, and Blood Institute; School of Medicine, New York University; York University; Juvenile Diabetes Research Foundation International","keywords":"Rage (emotion); Signal transduction; Glycation; Cell biology; Receptor; Inflammation; Extracellular; Chemistry; HMGB1; Biology; Biochemistry; Neuroscience; Immunology","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0006325076,0.00009606905,0.00009863344,0.000103861,0.00009470494,0.00002292521,0.00006780882,0.00008038507,0.0001320632],"category_scores_gemma":[0.0002043648,0.00007081972,0.00006790231,0.0002671363,0.0002409395,0.00001123149,0.00003849491,0.00004247967,0.0000104302],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00001504807,"about_ca_system_score_gemma":0.0001249216,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000004302364,"about_ca_topic_score_gemma":0.000004517608,"domain_scores_codex":[0.9985843,0.0000510604,0.0003255262,0.0005809372,0.0002567518,0.0002013989],"domain_scores_gemma":[0.9988441,0.00000841922,0.0001645028,0.0005469597,0.0003621872,0.00007383911],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00003414197,0.00004399583,0.0002167641,0.00001423044,0.000009140235,0.00001665199,0.00002620958,0.0001734891,0.9937973,0.00001207454,0.001083259,0.004572733],"study_design_scores_gemma":[0.0001936788,0.00007331918,0.0001288582,0.00002353995,0.000005736258,0.00006052875,0.000008794448,0.00001204292,0.9849156,0.001004649,0.01347661,0.00009665188],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9739248,0.0001676226,0.02429662,0.0002229016,0.000736856,0.0002224805,0.000006038594,0.00001811999,0.0004045476],"genre_scores_gemma":[0.9938785,0.00002103379,0.0005337489,0.000009948952,0.0000870123,0.00001226755,0.0001289461,0.00001401764,0.005314548],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.02376287,"threshold_uncertainty_score":0.2887944,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01923520304407255,"score_gpt":0.2703225228442904,"score_spread":0.2510873198002178,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}