{"id":"W2289963017","doi":"10.1242/dev.130344","title":"OCT4 Activity during Conversion of Human Intermediately Reprogrammed Stem Cells to iPS Cells through MET","year":2015,"lang":"en","type":"article","venue":"Development","topic":"Pluripotent Stem Cells Research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":19,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"Canadian Institutes of Health Research","keywords":"SOX2; Biology; Reprogramming; KLF4; Homeobox protein NANOG; Induced pluripotent stem cell; Mesenchymal stem cell; Cell biology; Gene silencing; Stem cell; Endogeny; Embryonic stem cell; Cell; Genetics; Biochemistry","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0004355219,0.0001762142,0.0002187846,0.0000652033,0.00007073255,0.00001992909,0.0003178891,0.0001238849,0.00001485055],"category_scores_gemma":[0.00001502375,0.0001698347,0.00006023738,0.000129711,0.00005735318,0.000007576915,0.000581557,0.0001006242,0.00009141403],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001134283,"about_ca_system_score_gemma":0.0001903052,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00002939852,"about_ca_topic_score_gemma":0.00001360576,"domain_scores_codex":[0.9983741,0.00009504816,0.0002819456,0.0004723939,0.0003977109,0.0003787862],"domain_scores_gemma":[0.9990812,0.000008972678,0.0001089564,0.0004019546,0.0001677844,0.0002311087],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001723,0.0001222784,0.0009356948,0.00009809132,0.00006164105,0.00001372482,0.000902466,0.00001498471,0.994466,0.000001325307,0.001423229,0.001788256],"study_design_scores_gemma":[0.0007191204,0.0002508236,0.001946602,0.00002863015,0.000005487166,0.000002746373,0.0003020816,0.000002314072,0.9725593,0.00000200989,0.02399013,0.0001907546],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.998354,0.000053097,0.000289388,0.00003741706,0.0002199446,0.000409226,0.00000755869,0.00001686897,0.00061246],"genre_scores_gemma":[0.9953308,0.00001892881,0.002373082,0.0000394562,0.00004640199,0.00003633647,0.00003181908,0.00002282447,0.002100375],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0225669,"threshold_uncertainty_score":0.6925659,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0502337763526873,"score_gpt":0.2996378404300987,"score_spread":0.2494040640774114,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}