{"id":"W2289963017","doi":"10.1242/dev.130344","title":"OCT4 Activity during Conversion of Human Intermediately Reprogrammed Stem Cells to iPS Cells through MET","year":2015,"lang":"en","type":"article","venue":"Development","topic":"Pluripotent Stem Cells Research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":19,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"Canadian Institutes of Health Research","keywords":"SOX2; Biology; Reprogramming; KLF4; Homeobox protein NANOG; Induced pluripotent stem cell; Mesenchymal stem cell; Cell biology; Gene silencing; Stem cell; Endogeny; Embryonic stem cell; Cell; Genetics; Biochemistry","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00009538234,0.0001113879,0.00009362369,0.0001093822,0.00007950892,0.0002362385,0.00009195916,0.0001000287,0.0007584625],"category_scores_gemma":[0.00007501593,0.0000772692,0.000133095,0.00007383117,0.00008760703,0.0001076766,0.0001196028,0.0002545243,0.0002333351],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001735842,"about_ca_system_score_gemma":0.0001493605,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0007143343,"about_ca_topic_score_gemma":0.0008947218,"domain_scores_codex":[0.999918,0.00001207741,0.00001086272,0.00001533226,0.00002431077,0.00001942193],"domain_scores_gemma":[0.9999584,0.000008035544,0.000009081193,0.000006391775,0.000007336927,0.00001068027],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00004946842,0.000008833021,0.0002671856,0.000009522715,0.000001698598,0.00004681821,0.00001411575,0.00008429046,0.9984992,0.0001101526,0.00001544706,0.0008932967],"study_design_scores_gemma":[0.00000233225,0.0000447027,0.002129772,0.000001695181,0.000003573797,0.00008687873,0.00001368282,0.0005700932,0.9960355,0.00002569066,0.001084597,0.000001351109],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9944715,0.0003088137,0.002798542,0.00003168797,0.00001014685,0.00002154744,0.0002783001,0.00004072134,0.002038767],"genre_scores_gemma":[0.9946683,0.0002053862,0.001569722,0.00002551522,0.000002624823,0.00001688993,0.0005631278,0.0000157048,0.00293263],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0007584625,"threshold_uncertainty_score":0.00253731,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0502337763526873,"score_gpt":0.2996378404300987,"score_spread":0.2494040640774114,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}