{"id":"W2289967391","doi":"10.1111/bcpt.12536","title":"Effect of Omeprazole and Dextromethorphan on the Urinary Metabolic Ratio of Flurbiprofen","year":2015,"lang":"en","type":"article","venue":"Basic & Clinical Pharmacology & Toxicology","topic":"Pharmacogenetics and Drug Metabolism","field":"Pharmacology, Toxicology and Pharmaceutics","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"","keywords":"Dextromethorphan; Omeprazole; Flurbiprofen; CYP2C19; Pharmacology; CYP2C9; CYP2D6; Drug; Drug metabolism; Medicine; CYP3A4; Cytochrome P450; Drug interaction; Dextrorphan; Pharmacogenetics; Internal medicine; Chemistry; Metabolism; Genotype; Biochemistry","routes":{"ca_aff":false,"ca_fund":false,"ca_venue":false,"about_ca":true,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0004541037,0.0006633915,0.001089821,0.0004284544,0.0002255477,0.0004023302,0.0002763431,0.0007461879,0.001466634],"category_scores_gemma":[0.001527275,0.0002462845,0.0006623482,0.0003963133,0.0002852959,0.0004471762,0.0002437538,0.0006838419,0.0002396635],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002459508,"about_ca_system_score_gemma":0.0003074768,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0009428177,"about_ca_topic_score_gemma":0.0008810451,"domain_scores_codex":[0.9994957,0.0001871936,0.00002959658,0.0001119905,0.0001021495,0.0000734257],"domain_scores_gemma":[0.9994344,0.0001494183,0.0001281661,0.00005162812,0.00005685244,0.0001795047],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.3186951,0.009131875,0.02714244,0.0008207131,0.001242648,0.001084993,0.0003718648,0.001002383,0.5466772,0.0001474424,0.0009972003,0.09268623],"study_design_scores_gemma":[0.005636299,0.1584093,0.3716995,0.0000860234,0.001632385,0.002046023,0.000420976,0.007518341,0.4449967,0.0001769775,0.007259257,0.0001180305],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9940276,0.004550816,0.0003430158,0.0001047129,0.00006981588,0.00006443079,0.0002946557,0.00005051249,0.0004945485],"genre_scores_gemma":[0.9975898,0.0007437594,0.0006069812,0.00009890638,0.00004519704,0.00003080408,0.0002684151,0.00001777937,0.000598376],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001466634,"threshold_uncertainty_score":0.004906356,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.2065157568213443,"score_gpt":0.5175748918779414,"score_spread":0.311059135056597,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}