{"id":"W2289969484","doi":"10.1021/acs.molpharmaceut.6b00030","title":"Uptake Mechanism and Direct Translocation of a New CPP for siRNA Delivery","year":2016,"lang":"en","type":"article","venue":"Molecular Pharmaceutics","topic":"RNA Interference and Gene Delivery","field":"Biochemistry, Genetics and Molecular Biology","cited_by":41,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Waterloo","funders":"","keywords":"Internalization; Endocytic cycle; Chemistry; Cell biology; Endosome; Intracellular; Chromosomal translocation; Cell-penetrating peptide; RNA interference; Gene delivery; Small interfering RNA; Cell; Endocytosis; Biochemistry; Biophysics; Transfection; RNA; Biology; Gene","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001167483,0.0001334391,0.0001337334,0.00003948429,0.00002885399,0.000008835352,0.000124357,0.0001014436,0.00001167457],"category_scores_gemma":[0.00003222602,0.0001091028,0.00009623545,0.00004226123,0.00004275261,0.000005098601,0.00003742709,0.00002921431,0.000002724698],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000007284408,"about_ca_system_score_gemma":0.00007218757,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000007262454,"about_ca_topic_score_gemma":0.000005951555,"domain_scores_codex":[0.9992534,0.00002567472,0.0001947471,0.0002571823,0.00009030445,0.0001786934],"domain_scores_gemma":[0.9995292,0.00001241133,0.00006727606,0.0001917802,0.000104534,0.00009474892],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001336582,0.00002478112,0.00003627795,0.00002126547,0.00008506836,0.000001609629,0.00004071445,0.000007721609,0.9392925,0.0002643702,0.000463547,0.0596285],"study_design_scores_gemma":[0.001159082,0.0002513655,0.00003366514,0.00003073375,0.00006377925,0.00000701442,0.00001695318,0.0001678845,0.9786941,0.0007126419,0.01871444,0.0001483399],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.8836869,0.00254939,0.1128781,0.0002876166,0.0001147377,0.0002538923,0.0000475101,0.000009866496,0.0001719935],"genre_scores_gemma":[0.9947984,0.002170767,0.001945488,0.00040833,0.00007703067,0.00001693646,0.00002213178,0.00002290063,0.0005380355],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.1111115,"threshold_uncertainty_score":0.4449084,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02822106598278252,"score_gpt":0.295967477724338,"score_spread":0.2677464117415554,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}