{"id":"W2290000235","doi":"10.2147/ndt.s98511","title":"Low-dose oral prolonged-release oxycodone/naloxone for chronic pain in elderly patients with cognitive impairment: an efficacy–tolerability pilot study","year":2016,"lang":"en","type":"article","venue":"Neuropsychiatric Disease and Treatment","topic":"Pain Management and Opioid Use","field":"Medicine","cited_by":11,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"Mundipharma Pharmaceuticals srl","keywords":"Medicine; Tolerability; Anesthesia; Oxycodone; Adverse effect; Chronic pain; Dementia; Clinical endpoint; Montreal Cognitive Assessment; Visual analogue scale; Internal medicine; Physical therapy; Opioid; Randomized controlled trial; Disease","routes":{"ca_aff":false,"ca_fund":false,"ca_venue":false,"about_ca":true,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.0002912019,0.0005246019,0.0005464802,0.0002883497,0.0001871865,0.00005029231,0.000105661,0.00004597556,0.0000491482],"category_scores_gemma":[0.0001336872,0.0003186474,0.0001386534,0.0003730317,0.0001062993,0.0001892897,0.00004388479,0.0001019749,0.00003014298],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002599831,"about_ca_system_score_gemma":0.0002342469,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00009128176,"about_ca_topic_score_gemma":0.0007568341,"domain_scores_codex":[0.997066,0.0004244382,0.0004582466,0.001047469,0.0003924438,0.0006113856],"domain_scores_gemma":[0.9981368,0.0002655737,0.000161636,0.0006233499,0.0001263095,0.0006863878],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.01978394,0.03855365,0.8396029,0.0001739817,0.0003068646,0.00009346133,0.0002643364,0.00000297204,0.00001546873,0.000006012871,0.00009441476,0.101102],"study_design_scores_gemma":[0.05422556,0.0396293,0.9037651,0.0001738196,0.001284943,6.989303e-7,0.00004773677,0.0000422972,0.000002620005,0.00004631026,0.0004429706,0.0003385863],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9897653,0.0002727118,0.0002106004,0.0005098463,0.000105188,0.008807331,0.0001827373,0.0001212402,0.00002503511],"genre_scores_gemma":[0.9974689,0.0001332478,0.0001823917,0.0002584446,0.0001677218,0.001045378,0.0003148379,0.00006918401,0.0003598445],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.1007634,"threshold_uncertainty_score":0.9999266,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01837099936613492,"score_gpt":0.2728395829648775,"score_spread":0.2544685835987426,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}