{"id":"W2290000235","doi":"10.2147/ndt.s98511","title":"Low-dose oral prolonged-release oxycodone/naloxone for chronic pain in elderly patients with cognitive impairment: an efficacy–tolerability pilot study","year":2016,"lang":"en","type":"article","venue":"Neuropsychiatric Disease and Treatment","topic":"Pain Management and Opioid Use","field":"Medicine","cited_by":11,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"Mundipharma Pharmaceuticals srl","keywords":"Medicine; Tolerability; Anesthesia; Oxycodone; Adverse effect; Chronic pain; Dementia; Clinical endpoint; Montreal Cognitive Assessment; Visual analogue scale; Internal medicine; Physical therapy; Opioid; Randomized controlled trial; Disease","routes":{"ca_aff":false,"ca_fund":false,"ca_venue":false,"about_ca":true,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.002026305,0.0008320311,0.001048032,0.0001977559,0.0002960742,0.0003941403,0.0005381241,0.0004370508,0.001855317],"category_scores_gemma":[0.001392106,0.0002966718,0.0008511774,0.0002016372,0.0007059399,0.0005081761,0.0003412313,0.0009522815,0.0003709306],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002903324,"about_ca_system_score_gemma":0.001195919,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0007747731,"about_ca_topic_score_gemma":0.001609212,"domain_scores_codex":[0.9994604,0.0002542399,0.00006280666,0.00005302537,0.0001063447,0.0000631666],"domain_scores_gemma":[0.9985515,0.0003012019,0.0003846982,0.0001161539,0.0001830663,0.000463282],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"randomized_trial","study_design_scores_codex":[0.5928057,0.1567736,0.07338028,0.002096127,0.002059052,0.0006773988,0.0009568834,0.0008353128,0.05356012,0.00007619123,0.001069998,0.1157094],"study_design_scores_gemma":[0.09040228,0.8297048,0.07612234,0.00003511894,0.0004475285,0.0002756616,0.0001086137,0.0004394655,0.001808191,0.00002000427,0.0006157506,0.00002020833],"study_design_candidate":"randomized_trial","study_design_consensus":"randomized_trial","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9989309,0.0002798582,0.0001218558,0.00002448018,0.00001065615,0.000373459,0.0001097886,0.000006803814,0.0001423038],"genre_scores_gemma":[0.9972716,0.0005763738,0.000660999,0.0001540338,0.0001415575,0.0005110073,0.00034107,0.000003141705,0.0003401253],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002026305,"threshold_uncertainty_score":0.01071626,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01837099936613492,"score_gpt":0.2728395829648775,"score_spread":0.2544685835987426,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}