{"id":"W2290003209","doi":"10.1128/msphere.00080-15","title":"The Zinc Finger Protein Mig1 Regulates Mitochondrial Function and Azole Drug Susceptibility in the Pathogenic Fungus Cryptococcus neoformans","year":2016,"lang":"en","type":"article","venue":"mSphere","topic":"Fungal Infections and Studies","field":"Medicine","cited_by":51,"is_retracted":false,"has_abstract":true,"ca_institutions":"Canada's Michael Smith Genome Sciences Centre; University of British Columbia","funders":"National Institute of Allergy and Infectious Diseases; National Institutes of Health; Burroughs Wellcome Fund","keywords":"Cryptococcus neoformans; Biology; Mitochondrion; Saccharomyces cerevisiae; Microbiology; Antifungal drug; Cell biology; Genetics; Gene; Candida albicans","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003600906,0.0001341863,0.0001563922,0.00001726484,0.0003826814,0.00004008777,0.00006845736,0.00006408388,0.0001513652],"category_scores_gemma":[0.0001395467,0.00005514882,0.00007646834,0.0001385042,0.000166227,0.00008483329,0.00004892054,0.0001598628,0.00004274039],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00005354849,"about_ca_system_score_gemma":0.00003326683,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001467922,"about_ca_topic_score_gemma":0.002792348,"domain_scores_codex":[0.9990441,0.0001053137,0.0002218505,0.0002155326,0.0001585697,0.0002546647],"domain_scores_gemma":[0.999301,0.0001917924,0.00005310828,0.0003508771,0.00006444011,0.00003882779],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"observational","study_design_scores_codex":[0.003093701,0.0007710985,0.3055496,0.0003015754,0.0003204769,0.00004382198,0.005028043,0.000009455611,0.4467247,0.003052148,0.0896783,0.1454271],"study_design_scores_gemma":[0.003562156,0.0007705025,0.8714935,0.0002632302,0.0001163874,0.00003701397,0.002766996,0.00006332692,0.003109751,0.004250123,0.1132974,0.0002696298],"study_design_candidate":"observational","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9916959,0.001306039,0.00004489066,0.003627078,0.0002535974,0.001048428,0.000005093044,0.00003941856,0.001979497],"genre_scores_gemma":[0.9946012,0.00007969275,0.00005355522,0.000121063,0.0003253112,0.0002242208,0.000002042371,0.00001101602,0.004581846],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.5659438,"threshold_uncertainty_score":0.2943315,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.009019558515006458,"score_gpt":0.2287840070364029,"score_spread":0.2197644485213965,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}