{"id":"W2290120390","doi":"10.1111/xen.12225","title":"First update of the International Xenotransplantation Association consensus statement on conditions for undertaking clinical trials of porcine islet products in type 1 diabetes – Chapter 3: Porcine islet product manufacturing and release testing criteria","year":2016,"lang":"en","type":"article","venue":"Xenotransplantation","topic":"Xenotransplantation and immune response","field":"Medicine","cited_by":25,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Alberta","funders":"","keywords":"Xenotransplantation; Islet; Medicine; Statement (logic); Diabetes mellitus; Product (mathematics); Internal medicine; Transplantation; Endocrinology; Political science; Mathematics","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.003207116,0.0002188967,0.0006018418,0.0002534514,0.00009616491,0.00001708732,0.0001033027,0.000109251,0.00007290324],"category_scores_gemma":[0.002571169,0.0001481603,0.0001152069,0.0001794556,0.00009761686,0.0001463885,0.000009071199,0.000150891,0.000003236647],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001099079,"about_ca_system_score_gemma":0.0001281521,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00004463598,"about_ca_topic_score_gemma":0.00004626472,"domain_scores_codex":[0.9968648,0.0003717044,0.001713974,0.0004007632,0.0004071723,0.0002415846],"domain_scores_gemma":[0.9954401,0.0027704,0.001069895,0.0002306929,0.0004323682,0.00005650849],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00841914,0.0003904338,0.08193074,0.001593236,0.0003856121,0.00001139136,0.0009835204,0.0002132252,0.9004438,0.0007887977,0.0002743045,0.004565833],"study_design_scores_gemma":[0.008039817,0.000566356,0.3261484,0.002528138,0.0005134913,0.00002220851,0.00006406982,0.0006383093,0.6605868,0.0003107899,0.0003797408,0.0002019545],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9826202,0.00008228987,0.0004467258,0.01369016,0.000578967,0.001553004,0.0009195752,0.00002991967,0.00007918954],"genre_scores_gemma":[0.9968784,0.0008244908,0.001202369,0.0003117592,0.0001331296,0.00004440057,0.0004592144,0.00002963074,0.0001165862],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.2442176,"threshold_uncertainty_score":0.6041802,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.1206787382242195,"score_gpt":0.3875939756575952,"score_spread":0.2669152374333758,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}