{"id":"W2290255013","doi":"10.1021/acs.orglett.5b00765","title":"Rapid Access to 3-Aminoindazoles from Tertiary Amides","year":2015,"lang":"en","type":"article","venue":"Organic Letters","topic":"Advanced Synthetic Organic Chemistry","field":"Chemistry","cited_by":54,"is_retracted":false,"has_abstract":true,"ca_institutions":"Université de Montréal; Centre in Green Chemistry and Catalysis","funders":"Natural Sciences and Engineering Research Council of Canada; Fonds de recherche du Québec – Nature et technologies; Université de Montréal; Canada Research Chairs; Hydro-Québec; Canada Foundation for Innovation; Centre in Green Chemistry and Catalysis","keywords":"Chemistry; Amination; Intramolecular force; Nucleophile; Surface modification; Combinatorial chemistry; Sequence (biology); Ligand (biochemistry); Reductive amination; Catalysis; Organic chemistry; Receptor","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow","insufficient_payload"],"consensus_categories":["insufficient_payload"],"category_scores_codex":[0.00009248197,0.0003298686,0.0002955812,0.00004213911,0.00007023512,0.0001219641,0.0009812557,0.0001434728,0.005929096],"category_scores_gemma":[0.0003267303,0.0003347101,0.00007491215,0.0001845151,0.0001183704,0.0002833254,0.0004729457,0.0002968565,0.0007938],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000354834,"about_ca_system_score_gemma":0.0001004185,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00005834691,"about_ca_topic_score_gemma":0.00001408055,"domain_scores_codex":[0.9981743,0.00001725707,0.0003472831,0.0006188928,0.0003590623,0.0004832687],"domain_scores_gemma":[0.9983518,0.0001196829,0.0001170095,0.0009073547,0.00004679379,0.0004573545],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00002101884,0.000039572,0.002212816,0.00002108017,0.00004626771,0.00005547867,0.0005627842,0.000008707934,0.966911,0.000001649614,0.02634469,0.003774917],"study_design_scores_gemma":[0.0006160065,0.000004471678,0.0004632774,0.00005741474,0.00003629416,0.00002324221,0.0004358286,0.00001158285,0.9835224,0.0001575213,0.01424279,0.0004292073],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9846388,0.0001761249,0.001603712,0.01095961,0.0002553657,0.00007248432,0.00005810141,0.0003387864,0.001896986],"genre_scores_gemma":[0.9902345,0.0000099824,0.001526288,0.007062491,0.0007363351,0.00001636904,0.00005946596,0.0001091052,0.0002454584],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.01661134,"threshold_uncertainty_score":0.9999842,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01989665738926769,"score_gpt":0.2451304212846429,"score_spread":0.2252337638953752,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}