{"id":"W2290255013","doi":"10.1021/acs.orglett.5b00765","title":"Rapid Access to 3-Aminoindazoles from Tertiary Amides","year":2015,"lang":"en","type":"article","venue":"Organic Letters","topic":"Advanced Synthetic Organic Chemistry","field":"Chemistry","cited_by":54,"is_retracted":false,"has_abstract":true,"ca_institutions":"Université de Montréal; Centre in Green Chemistry and Catalysis","funders":"Natural Sciences and Engineering Research Council of Canada; Fonds de recherche du Québec – Nature et technologies; Université de Montréal; Canada Research Chairs; Hydro-Québec; Canada Foundation for Innovation; Centre in Green Chemistry and Catalysis","keywords":"Chemistry; Amination; Intramolecular force; Nucleophile; Surface modification; Combinatorial chemistry; Sequence (biology); Ligand (biochemistry); Reductive amination; Catalysis; Organic chemistry; Receptor","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.000265378,0.000652838,0.0004174598,0.0002851289,0.0002155202,0.0002111692,0.0005623461,0.000347633,0.002102194],"category_scores_gemma":[0.000194123,0.000255509,0.0002716942,0.0002241597,0.000199928,0.0003531237,0.000436625,0.0007523581,0.001098948],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003413204,"about_ca_system_score_gemma":0.0003985792,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0003226198,"about_ca_topic_score_gemma":0.001289158,"domain_scores_codex":[0.9998195,0.00002493717,0.00001642201,0.00002936457,0.00004520571,0.00006467408],"domain_scores_gemma":[0.999911,0.00001457862,0.00002038576,0.00001220144,0.00001833231,0.00002356743],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001402974,0.00009427291,0.0001243123,0.0002885062,0.00001295286,0.0005498762,0.0001191534,0.0005960391,0.9802469,0.001579876,0.0004913931,0.01575631],"study_design_scores_gemma":[0.0001141137,0.0007766066,0.001155886,0.00002173287,0.0000199014,0.0008903096,0.00003365889,0.001269061,0.9802265,0.0003551057,0.0151081,0.00002906366],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.87691,0.008827271,0.07481405,0.0004373875,0.0002146743,0.000533735,0.001196422,0.0009387932,0.03612758],"genre_scores_gemma":[0.9657452,0.004028221,0.02391784,0.00009605462,0.00004797108,0.0001553024,0.00063786,0.00005645542,0.00531511],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002102194,"threshold_uncertainty_score":0.007032573,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01989665738926769,"score_gpt":0.2451304212846429,"score_spread":0.2252337638953752,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}