{"id":"W2290262197","doi":"10.1126/scitranslmed.aad7666","title":"A dominant gain-of-function mutation in universal tyrosine kinase <i>SRC</i> causes thrombocytopenia, myelofibrosis, bleeding, and bone pathologies","year":2016,"lang":"en","type":"article","venue":"Science Translational Medicine","topic":"Chronic Lymphocytic Leukemia Research","field":"Medicine","cited_by":144,"is_retracted":false,"has_abstract":true,"ca_institutions":"Institute of Infection and Immunity","funders":"National Heart, Lung, and Blood Institute; NIHR Cambridge Biomedical Research Centre; NIHR BioResource; Vlaamse regering; Fonds Wetenschappelijk Onderzoek; Onderzoeksraad, KU Leuven; Imperial College London; British Heart Foundation; KU Leuven; National Institute for Health and Care Research; Medical Research Council; British Society for Haematology; NHS Blood and Transplant","keywords":"Myelofibrosis; Gain of function; Medicine; Proto-oncogene tyrosine-protein kinase Src; Tyrosine kinase; Mutation; Function (biology); Platelet; Cancer research; Internal medicine; Bone marrow; Biology; Receptor; Genetics; Gene","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["sts"],"consensus_categories":[],"category_scores_codex":[0.001254825,0.0001576253,0.0003818506,0.0005750722,0.0001105457,0.000009761146,0.0001269568,0.00006382656,0.0001258491],"category_scores_gemma":[0.0006507154,0.00009685776,0.00003195793,0.001016174,0.002719352,0.0004723427,0.00003948748,0.0001105411,0.000006407054],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.001127433,"about_ca_system_score_gemma":0.002419701,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000364744,"about_ca_topic_score_gemma":0.00009801819,"domain_scores_codex":[0.997672,0.00004093266,0.0004219173,0.0004484899,0.001050875,0.0003657785],"domain_scores_gemma":[0.9987958,0.0004299997,0.0001082447,0.0002136518,0.0002847299,0.0001675885],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"observational","study_design_scores_codex":[0.0009544973,0.00008923379,0.007127441,0.0001398465,0.00001261141,0.0001501718,0.00150153,0.00003370184,0.9713618,0.00518857,0.0001062919,0.01333433],"study_design_scores_gemma":[0.09376312,0.005143614,0.5987275,0.004837262,0.0003960803,0.001486176,0.003503993,0.008826548,0.2717081,0.009374013,0.001496979,0.0007365739],"study_design_candidate":"bench_or_experimental","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9860285,0.001295494,0.003038588,0.008032871,0.0002243652,0.000506,0.00001287365,0.00003267777,0.0008286602],"genre_scores_gemma":[0.9983829,0.000376155,0.0008211968,0.0001097893,0.0001129501,0.00001280766,0.0000101293,0.00001133258,0.0001627119],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.6996537,"threshold_uncertainty_score":0.9999947,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02917084554683468,"score_gpt":0.3120914435771577,"score_spread":0.282920598030323,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}