{"id":"W2290266665","doi":"10.1242/jeb.132027","title":"Decreased force enhancement in skeletal muscle sarcomeres with a deletion in titin","year":2016,"lang":"en","type":"article","venue":"Journal of Experimental Biology","topic":"Cardiomyopathy and Myosin Studies","field":"Medicine","cited_by":61,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Calgary","funders":"Natural Sciences and Engineering Research Council of Canada; Canadian HIV Trials Network, Canadian Institutes of Health Research; Canadian Institutes of Health Research; Canadian Network for Research and Innovation in Machining Technology, Natural Sciences and Engineering Research Council of Canada; Alberta Innovates - Technology Futures; National Science Foundation; Northern Arizona University; Killam Trusts; W. M. Keck Foundation","keywords":"Titin; Sarcomere; Myofibril; Biophysics; Myosin; Actin; Chemistry; Contraction (grammar); Muscle contraction; Obscurin; Stiffness; Nebulin; Anatomy; Materials science; Myocyte; Biology; Cell biology; Biochemistry; Composite material","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001818151,0.00008672747,0.0002995859,0.0001559536,0.00001424572,0.000002089193,0.00003846138,0.00004343101,0.0000832173],"category_scores_gemma":[0.00003444379,0.00004754824,0.00006735233,0.00007816024,0.00009229767,0.00005225642,0.00002427767,0.00007610219,0.000004422493],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000163035,"about_ca_system_score_gemma":0.00004192097,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00002831861,"about_ca_topic_score_gemma":0.00002809454,"domain_scores_codex":[0.9993097,0.00005420671,0.000288434,0.0001011521,0.00008446877,0.0001620133],"domain_scores_gemma":[0.9996814,0.00005268422,0.0001122732,0.00006371494,0.00003720113,0.00005272872],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0006628633,0.0002773178,0.02394332,0.000004883124,0.00003662506,0.0001477832,0.0003477885,1.821946e-7,0.966945,0.0001198919,0.00008415263,0.007430193],"study_design_scores_gemma":[0.01244715,0.005824106,0.08485871,0.0005985427,0.00003125469,0.0006813346,0.002609466,0.000002576413,0.8863616,0.0001138882,0.006298672,0.0001727316],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9950587,0.003003739,0.0002224249,0.0005234262,0.0000961239,0.0001197726,0.00000158272,0.000002864937,0.0009713253],"genre_scores_gemma":[0.9989373,0.0002130892,0.0004988358,0.0001849623,0.00009671708,0.00001183616,0.000001499633,0.000005652393,0.00005010113],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.08058343,"threshold_uncertainty_score":0.1938961,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01466485792837465,"score_gpt":0.2996130790866106,"score_spread":0.2849482211582359,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}