{"id":"W2290266665","doi":"10.1242/jeb.132027","title":"Decreased force enhancement in skeletal muscle sarcomeres with a deletion in titin","year":2016,"lang":"en","type":"article","venue":"Journal of Experimental Biology","topic":"Cardiomyopathy and Myosin Studies","field":"Medicine","cited_by":61,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Calgary","funders":"Natural Sciences and Engineering Research Council of Canada; Canadian HIV Trials Network, Canadian Institutes of Health Research; Canadian Institutes of Health Research; Canadian Network for Research and Innovation in Machining Technology, Natural Sciences and Engineering Research Council of Canada; Alberta Innovates - Technology Futures; National Science Foundation; Northern Arizona University; Killam Trusts; W. M. Keck Foundation","keywords":"Titin; Sarcomere; Myofibril; Biophysics; Myosin; Actin; Chemistry; Contraction (grammar); Muscle contraction; Obscurin; Stiffness; Nebulin; Anatomy; Materials science; Myocyte; Biology; Cell biology; Biochemistry; Composite material","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002376573,0.0004245639,0.000348762,0.0004700009,0.0001752745,0.0001360352,0.0002333938,0.0004782995,0.002171973],"category_scores_gemma":[0.0003280581,0.000225417,0.0002954096,0.0001320627,0.0004457716,0.0002209855,0.0003434671,0.0004625121,0.0002791907],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00009612679,"about_ca_system_score_gemma":0.00007090727,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002429911,"about_ca_topic_score_gemma":0.0003397386,"domain_scores_codex":[0.9998088,0.00002486434,0.00003082117,0.00005640774,0.00004692815,0.00003212827],"domain_scores_gemma":[0.9995005,0.00009440022,0.0001629219,0.00004635355,0.00004026141,0.000155587],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001010666,0.00001700753,0.0004910951,0.00001461956,0.000005666373,0.0001218261,0.00001412175,0.00001259002,0.9989353,0.0000195161,0.000008103239,0.0002590055],"study_design_scores_gemma":[0.00008542961,0.00183248,0.137652,0.00002283495,0.00007857913,0.004741559,0.0001458775,0.0007284879,0.8531972,0.0001112081,0.001388608,0.00001577215],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9984894,0.0002872501,0.0007533776,0.00003278018,0.00001387201,0.000005905771,0.0001199355,0.00002742195,0.0002699023],"genre_scores_gemma":[0.9974246,0.0002088249,0.00102264,0.00003595974,0.00001150793,0.00001883641,0.0002148441,0.00002640493,0.001036384],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002171973,"threshold_uncertainty_score":0.007265925,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01466485792837465,"score_gpt":0.2996130790866106,"score_spread":0.2849482211582359,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}